The future of genetic research on neurodegeneration

被引：15

作者：

Van Broeckhoven, Christine ^{[1
,2
]}

机构：

[1] VIB, Neurodegenerat Brain Dis Grp, Dept Mol Genet, Antwerp, Belgium

[2] Univ Antwerp, Neurogenet Lab, Inst Born Bunge, B-2020 Antwerp, Belgium

来源：

NATURE MEDICINE | 2010年 / 16卷 / 11期

关键词：

FAMILIAL ALZHEIMERS-DISEASE; AMYOTROPHIC-LATERAL-SCLEROSIS; FRONTOTEMPORAL LOBAR DEGENERATION; GENOME-WIDE ASSOCIATION; IDENTIFIES VARIANTS; MISSENSE MUTATIONS; TARDBP MUTATIONS; LOCUS; PROGRANULIN; DEMENTIA;

D O I：

10.1038/nm.2225

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Why, with all the progress in the field of neurodegeneration, do we still lack disease-modifying drugs that tackle the primary defect of severe cell loss? How much progress has been made toward this goal? Have we spent our time and resources wisely? And, most important, is there room for improvement? This commentary highlights several problems faced by researchers in studying the genetic etiology of neurodegenerative diseases and seeks to provide direction in overcoming some of these obstacles.

引用

页码：1215 / 1217

页数：3

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