Genomic Evolution of SARS-CoV-2 Virus in Immunocompromised Patient, Ireland

被引：19

作者：

Lynch, Maureen ^{[1
]}

Macori, Guerrino ^{[2
]}

Fanning, Seamus ^{[2
]}

O'Regan, Edel ^{[1
]}

Hunt, Eoin ^{[1
]}

O'Callaghan, Dermot ^{[1
]}

McCullagh, Brian ^{[1
]}

Jennings, Cormac ^{[1
]}

Fortune, Anne ^{[1
]}

机构：

[1] Mater Misericordiae Univ Hosp, Dublin, Ireland

[2] Univ Coll Dublin, Ctr Food Safety, Sch Publ Hlth Physiotherapy & Sports Sci, Dublin, Ireland

来源：

EMERGING INFECTIOUS DISEASES | 2021年 / 27卷 / 09期

关键词：

2019 novel coronavirus disease; B-cell therapy; coronavirus disease; COVID-19; immunocompromised; respiratory infections; SARS-CoV-2; severe acute respiratory syndrome coronavirus 2; superinfection; virus evolution; viruses; zoonoses;

D O I：

10.3201/eid2709.211159

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We examined virus genomic evolution in an immunocompromised patient with prolonged severe acute respiratory syndrome coronavirus 2 infection. Genomic sequencing revealed genetic variation during infection: 3 intrahost mutations and possible superinfection with a second strain of the virus. Prolonged infection in immunocompromised patients may lead to emergence of new virus variants.

引用

页码：2499 / 2501

页数：3

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