Imaging of hepatic toxicity of systemic therapy in a tertiary cancer centre: chemotherapy, haematopoietic stem cell transplantation, molecular targeted therapies, and immune checkpoint inhibitors

被引:42
作者
Alessandrino, F. [1 ,2 ]
Tirumani, S. H. [2 ]
Krajewski, K. M. [1 ,2 ]
Shinagare, A. B. [1 ,2 ]
Jagannathan, J. P. [1 ,2 ]
Ramaiya, N. H. [1 ,2 ]
Di Salvo, D. N. [1 ,2 ]
机构
[1] Harvard Med Sch, Dept Imaging, Dana Farber Canc Inst, 450 Brookline Ave, Boston, MA 02215 USA
[2] Harvard Med Sch, Brigham & Womens Hosp, Dept Radiol, 75 Francis St, Boston, MA 02115 USA
关键词
FATTY LIVER-DISEASE; NODULAR REGENERATIVE HYPERPLASIA; OXALIPLATIN-BASED CHEMOTHERAPY; PORTAL-VEIN THROMBOSIS; BUDD-CHIARI-SYNDROME; VENOOCCLUSIVE DISEASE; ADVERSE EVENTS; MEDROXYPROGESTERONE ACETATE; FULMINANT-HEPATITIS; VASCULAR DISORDERS;
D O I
10.1016/j.crad.2017.04.003
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
The purpose of this review is to familiarise radiologists with the spectrum of hepatic toxicity seen in the oncology setting, in view of the different systemic therapies used in cancer patients. Drug-induced liver injury can manifest in various forms, and anti-neoplastic agents are associated with different types of hepatotoxicity. Although chemotherapy-induced liver injury can present as hepatitis, steatosis, sinusoidal obstruction syndrome, and chronic parenchymal damages, molecular targeted therapy-associated liver toxicity ranges from mild liver function test elevation to fulminant life-threatening acute liver failure. The recent arrival of immune checkpoint inhibitors in oncology has introduced a new range of immune-related adverse events, with differing mechanisms of liver toxicity and varied imaging presentation of liver injury. High-dose chemotherapy regimens for haematopoietic stem cell transplantation are associated with sinusoidal obstruction syndrome. Management of hepatic toxicity depends on the clinical scenario, the drug in use, and the severity of the findings. In this article, we will (1) present the most common types of oncological drugs associated with hepatic toxicity and associated liver injuries; (2) illustrate imaging findings of hepatic toxicities and the possible differential diagnosis; and (3) provide a guide for management of these conditions. (C) 2017 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:521 / 533
页数:13
相关论文
共 101 条
[51]   PELIOSIS HEPATIS INDUCED BY 6-THIOGUANINE ADMINISTRATION [J].
LARREY, D ;
FRENEAUX, E ;
BERSON, A ;
BABANY, G ;
DEGOTT, C ;
VALLA, D ;
PESSAYRE, D ;
BENHAMOU, JP .
GUT, 1988, 29 (09) :1265-1269
[52]   Prognostic value of Doppler-ultrasonography in hepatic vend-occlusive disease - A study of 71 children [J].
Lassau, N ;
Auperin, A ;
Leclere, J ;
Bennaceur, A ;
Valteau-Couanet, D ;
Hartmann, O .
TRANSPLANTATION, 2002, 74 (01) :60-66
[53]   Medical progress: Drug-induced hepatotoxicity [J].
Lee, WM .
NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (05) :474-485
[54]  
LEE WM, 2011, HEPATOLOGY, V1, P22
[55]   Fulminant hepatic failure secondary to erlotinib [J].
Liu, Weitian ;
Makrauer, Frederick L. ;
Qamar, Amir A. ;
Jaenne, Pasi A. ;
Odze, Robert D. .
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2007, 5 (08) :917-920
[56]   A CASE OF PELIOSIS HEPATIS IN ASSOCIATION WITH TAMOXIFEN THERAPY [J].
LOOMUS, GN ;
ANEJA, P ;
BOTA, RA .
AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 1983, 80 (06) :881-883
[57]   Drug insight: gastrointestinal and hepatic adverse effects of molecular-targeted agents in cancer therapy [J].
Loriot, Yohann ;
Perlemuter, Gabriel ;
Malka, David ;
Penault-Lorca, Frederique ;
Boige, Valerie ;
Deutsch, Eric ;
Massard, Christophe ;
Armand, Jean Pierre ;
Soria, Jean-Charles .
NATURE CLINICAL PRACTICE ONCOLOGY, 2008, 5 (05) :268-278
[58]   Gefitinib or Chemotherapy for Non-Small-Cell Lung Cancer with Mutated EGFR. [J].
Maemondo, Makoto ;
Inoue, Akira ;
Kobayashi, Kunihiko ;
Sugawara, Shunichi ;
Oizumi, Satoshi ;
Isobe, Hiroshi ;
Gemma, Akihiko ;
Harada, Masao ;
Yoshizawa, Hirohisa ;
Kinoshita, Ichiro ;
Fujita, Yuka ;
Okinaga, Shoji ;
Hirano, Haruto ;
Yoshimori, Kozo ;
Harada, Toshiyuki ;
Ogura, Takashi ;
Ando, Masahiro ;
Miyazawa, Hitoshi ;
Tanaka, Tomoaki ;
Saijo, Yasuo ;
Hagiwara, Koichi ;
Morita, Satoshi ;
Nukiwa, Toshihiro .
NEW ENGLAND JOURNAL OF MEDICINE, 2010, 362 (25) :2380-2388
[59]   Acute exacerbation and reactivation of chronic hepatitis C virus infection in cancer patients [J].
Mahale, Parag ;
Kontoyiannis, Dimitrios P. ;
Chemaly, Roy F. ;
Jiang, Ying ;
Hwang, Jessica P. ;
Davila, Marta ;
Torres, Harrys A. .
JOURNAL OF HEPATOLOGY, 2012, 57 (06) :1177-1185
[60]   Liver Injury Induced by Anticancer Chemotherapy and Radiation Therapy [J].
Maor, Y. ;
Malnick, S. .
INTERNATIONAL JOURNAL OF HEPATOLOGY, 2013, 2013