共 20 条
Thalidomide in induction treatment increases the very good partial response rate before and after high-dose therapy in previously untreated multiple myeloma
被引:101
作者:

Lokhorst, Henk M.
论文数: 0 引用数: 0
h-index: 0
机构:
Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands

Schmidt-Wolf, Ingo
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h-index: 0
机构:
German GMMG, Heidelberg, Germany Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands

Sonneveld, Pieter
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h-index: 0
机构:
Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands

van der Holt, Bronno
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h-index: 0
机构:
Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands

Martin, Hans
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h-index: 0
机构:
German GMMG, Heidelberg, Germany Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands

Barge, Rene
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h-index: 0
机构:
Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands

Bertsch, Uta
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h-index: 0
机构:
German GMMG, Heidelberg, Germany Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands

Schlenzka, Jana
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h-index: 0
机构:
German GMMG, Heidelberg, Germany Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands

Bos, Gerard M. J.
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h-index: 0
机构:
Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands

Croockewit, Sandra
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Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands

Zweegman, Sonja
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Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands

Breitkreutz, Iris
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h-index: 0
机构:
German GMMG, Heidelberg, Germany Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands

Joosten, Peter
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Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands

Scheid, Christof
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h-index: 0
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German GMMG, Heidelberg, Germany Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands

van Marwijk-Kooy, Marinus
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机构:
Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands

Salwender, Hans-Juergen
论文数: 0 引用数: 0
h-index: 0
机构:
German GMMG, Heidelberg, Germany Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands

van Oers, Marinus H. J.
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h-index: 0
机构:
Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands

Schaafsma, Ron
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Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands

Naumann, Ralph
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German GMMG, Heidelberg, Germany Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands

Sinnige, Harm
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h-index: 0
机构:
Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands

Blau, Igor
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h-index: 0
机构:
German GMMG, Heidelberg, Germany Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands

Delforge, Michel
论文数: 0 引用数: 0
h-index: 0
机构:
Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands

de Weerdt, Okke
论文数: 0 引用数: 0
h-index: 0
机构:
Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands

Wijermans, Pierre
论文数: 0 引用数: 0
h-index: 0
机构:
Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands

Wittebol, Shulamiet
论文数: 0 引用数: 0
h-index: 0
机构:
Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands

Duersen, Ulrich
论文数: 0 引用数: 0
h-index: 0
机构:
German GMMG, Heidelberg, Germany Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands

Vellenga, Edo
论文数: 0 引用数: 0
h-index: 0
机构:
Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands

Goldschmidt, Hartmut
论文数: 0 引用数: 0
h-index: 0
机构:
German GMMG, Heidelberg, Germany Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands
机构:
[1] Dutch Belgian Hematooncol Cooperat Grp HOVON, Amsterdam, Netherlands
[2] German GMMG, Heidelberg, Germany
关键词:
thalidomide;
untreated multiple myeloma;
D O I:
10.3324/haematol.11644
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
In the prospective phase 3 HOVON-50/GMMG-1-1D3 trial, patients randomized to TAD (thalidomide, doxorubicin, dexamethasone) had a significantly higher response rate (at least PR) after induction compared with patients randomized to VAD (vincristine, adriamycin, dexamethasone, 72% vs. 54%, p<0.001). Complete remission (CR) and very good partial remission (VGPR) were also higher afterTAD. After High Dose melphalan 200mg/m(2) response was comparable in both arms, 76% and 79% respectively. However, CR plus VGPR were significantly higher in the patients randomized to TAD (49% vs. 32%, p<0.001). CTC grade 3-4 adverse events were similar in both arms.
引用
收藏
页码:124 / 127
页数:4
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机构: Erasmus MC, Rotterdam, Netherlands

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机构: Erasmus MC, Rotterdam, Netherlands

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机构: Erasmus MC, Rotterdam, Netherlands

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机构: Erasmus MC, Rotterdam, Netherlands

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机构: Erasmus MC, Rotterdam, Netherlands

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机构: Univ Rotterdam Hosp, Dept Haematol, NL-3000 CA Rotterdam, Netherlands

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机构: Univ Rotterdam Hosp, Dept Haematol, NL-3000 CA Rotterdam, Netherlands

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机构: Univ Rotterdam Hosp, Dept Haematol, NL-3000 CA Rotterdam, Netherlands

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机构: Univ Rotterdam Hosp, Dept Haematol, NL-3000 CA Rotterdam, Netherlands

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机构: Univ Rotterdam Hosp, Dept Haematol, NL-3000 CA Rotterdam, Netherlands

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机构: Univ Rotterdam Hosp, Dept Haematol, NL-3000 CA Rotterdam, Netherlands

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机构: Univ Rotterdam Hosp, Dept Haematol, NL-3000 CA Rotterdam, Netherlands

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机构: Univ Rotterdam Hosp, Dept Haematol, NL-3000 CA Rotterdam, Netherlands

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机构: Univ Rotterdam Hosp, Dept Haematol, NL-3000 CA Rotterdam, Netherlands

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机构: Univ Rotterdam Hosp, Dept Haematol, NL-3000 CA Rotterdam, Netherlands

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机构: Univ Rotterdam Hosp, Dept Haematol, NL-3000 CA Rotterdam, Netherlands

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机构: Univ Rotterdam Hosp, Dept Haematol, NL-3000 CA Rotterdam, Netherlands

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机构: Univ Rotterdam Hosp, Dept Haematol, NL-3000 CA Rotterdam, Netherlands

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机构: Univ Rotterdam Hosp, Dept Haematol, NL-3000 CA Rotterdam, Netherlands

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h-index: 0
机构:
Univ Texas, MD Anderson Canc Ctr, Houston, TX 77030 USA Univ Texas, MD Anderson Canc Ctr, Houston, TX 77030 USA

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h-index: 0
机构:
Univ Texas, MD Anderson Canc Ctr, Houston, TX 77030 USA Univ Texas, MD Anderson Canc Ctr, Houston, TX 77030 USA

Delasalle, K
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h-index: 0
机构:
Univ Texas, MD Anderson Canc Ctr, Houston, TX 77030 USA Univ Texas, MD Anderson Canc Ctr, Houston, TX 77030 USA

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h-index: 0
机构:
Univ Texas, MD Anderson Canc Ctr, Houston, TX 77030 USA Univ Texas, MD Anderson Canc Ctr, Houston, TX 77030 USA