Recent Progress in the Development of Small-Molecule FtsZ Inhibitors as Chemical Tools for the Development of Novel Antibiotics

被引：33

作者：

Carro, Laura ^{[1
,2
]}

机构：

[1] Univ Salamanca, Dept Ciencias Farmaceut, Lab Quim Organ & Farmaceut, Fac Farm, Campus Miguel Unamuno, Salamanca 37007, Spain

[2] Univ East Anglia, Sch Pharm, Norwich Res Pk, Norwich NR4 7TJ, Norfolk, England

来源：

ANTIBIOTICS-BASEL | 2019年 / 8卷 / 04期

关键词：

FtsZ; bacterial cell division; small-molecule inhibitors; new antibiotics; antibiotic resistance; DIVISION PROTEIN FTSZ; CELL-DIVISION; ANTIBACTERIAL ACTIVITY; DERIVATIVES; DESIGN; TUBULIN; PRODRUG; POTENT; MODE; RESISTANCE;

D O I：

10.3390/antibiotics8040217

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Antibiotics are potent pharmacological weapons against bacterial pathogens, nevertheless their efficacy is becoming compromised due to the worldwide emergence and spread of multidrug-resistant bacteria or "superbugs". Antibiotic resistance is rising to such dangerous levels that the treatment of bacterial infections is becoming a clinical challenge. Therefore, urgent action is needed to develop new generations of antibiotics that will help tackle this increasing and serious public health problem. Due to its essential role in bacterial cell division, the tubulin-like protein FtsZ has emerged as a promising target for the development of novel antibiotics with new mechanisms of action. This review highlights the medicinal chemistry efforts towards the identification of small-molecule FtsZ inhibitors with antibacterial activity in the last three years.

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页数：29

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