Differences in Clinical Manifestations according to the Positivity of Interferon-γ Assay in Patients with Intestinal Tuberculosis

被引:5
作者
Jung, Hye Jin [1 ,2 ]
Kim, Young-Ho [3 ]
Kim, You Sun [1 ]
Jeong, Seong Yeon [1 ]
Park, Sung Won [1 ]
Seo, Ji Yeon [4 ]
Jung, Hyemi [3 ]
Im, Jong Pil [4 ]
Kim, Ji Won [4 ]
Hong, Sung Noh [3 ]
Lee, Kuk Lae [4 ]
机构
[1] Inje Univ, Coll Med, Dept Internal Med, Seoul, South Korea
[2] Int St Marys Hosp, Dept Hlth Promot Ctr, Inchon, South Korea
[3] Sungkyunkwan Univ, Sch Med, Dept Internal Med, Seoul, South Korea
[4] Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul, South Korea
关键词
Intestinal tuberculosis; Interferon-gamma assay; C-reactive protein; SACCHAROMYCES-CEREVISIAE ANTIBODY; CROHNS-DISEASE; RELEASE ASSAYS; METAANALYSIS; INFECTION; DIAGNOSIS; EPIDEMIOLOGY;
D O I
10.5009/gnl15439
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Intestinal tuberculosis (ITB) remains prevalent in Asia. An interferon-gamma assay (QuantiFERON-TB gold test [QFT]) is considered to be an effective supplementary tool for diagnosing ITB. We retrospectively analyzed the clinical features of ITB patients based on the initial results of QFT. A total of 109 patients with ITB were enrolled, and 82 patients (75.2%) showed positive QFT results. In the QFT-positive group, the mean age (44.1 +/- 12.0 years) was significantly higher than that in the QFT-negative group (37.0 +/- 14.8, p=0.0096). Abdominal pain (p=0.006) and diarrhea (p=0.030) were more frequent in the QFT-negative group. Further, C-reactive protein (CRP) levels were significantly higher in the QFT-negative group (6.4 +/- 9.9 mg/dL) than in the QFT-positive group (1.3 +/- 2.3, p<0.001). Multivariate analysis confirmed that younger age (p=0.016), diarrhea (p=0.042), and high levels of CRP (p=0.029) were independent predictors of QFT-negative results in patients with ITB. These results suggest that prior exposure to TB, reflected by QFT positivity, may cause mild inflammation in patients with ITB.
引用
收藏
页码:649 / 652
页数:4
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