Sarcomatoid renal cell carcinoma presenting in the oropharynx

被引:5
作者
Gammon, Bryan Leigh [1 ]
Gleason, Briana C. [2 ]
Thomas, Antoinette B. [3 ]
Cibull, Thomas Lee [3 ]
机构
[1] Northwestern Univ, Dept Dermatol, Chicago, IL 60611 USA
[2] Diagnost Pathol Med Grp, Dept Dermatol, Sacramento, CA USA
[3] Northshore Univ Hlth Syst, Dept Pathol, Evanston, IL USA
关键词
PRIMARY MALIGNANT-MELANOMA; ORAL-CAVITY; MYOEPITHELIAL CARCINOMA; MONOCLONAL-ANTIBODY; SALIVARY-GLANDS; TUMORS;
D O I
10.1111/j.1600-0560.2010.01578.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Metastasis stemming from a distant malignancy is far less common than an oropharyngeal primary and represents only 1% of all oral neoplasms. The difficulty in diagnosing a metastasis in the oropharynx may be compounded if the lesion is poorly differentiated and bears little resemblance to the primary tumor. We present the case of synchronous metastatic renal cell carcinoma of the mandibular gingiva in a woman with sarcomatoid clear cell renal cell carcinoma. The metastatic lesion was poorly differentiated and lacked expression of the renal cell carcinoma (RCC) antigen. In contrast, PAX-8 staining was strongly positive. This case serves to highlight the diagnostic difficulty posed by poorly differentiated lesions in the oropharynx and reinforces the sensitivity of the cell lineage-specific transcription factor PAX-8 in poorly differentiated RCC.
引用
收藏
页码:1255 / 1258
页数:4
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