Implication of extended-spectrum beta-lactamase enterobacteriaceae in nosocomial infections in neonates

Aims The, objectives of this study was to determine the incidence of extended-spectrum beta-lactamase (ESBLS) enterobaeteriaceae colonization and infection in hospitalized children. Methods This prospective study was conducted in a neonatal intensive care unit from 2000 to 2009 We recorded all isolations of ESBLs enterobacteriaceae from clinical simples that were obtained from hospitalized children Anorectal samples were taken at admission and every 10 days We systematically recorded cases of confirmed infections that was caused by ESBLs enterobacteriaceae. Results A total of 46 ESBLs pathogens (E coli 58 7 %. Enterbacter cloacae 10 8 %, Klebstella Pneumonia 19 5%. K. oxytoca (6 5%. Citrobacter 4 5%) were isolated during 10 years, the global incidence was 51 cases per 1000 admissions Three infants developed nosocomical infections. E coli sepsis and pneumonia and Eneterobactercloacae These patients were treated with carbapenem with significant clinical improvement ESBLs enterobacteriaceae were found first in Klebstella pneumonia and then preedominantly in E coli Current efforts have focused on monitoring proper hand hygiene. evaluation of potential reservoirs of bactetial aequisition and transmission, cohorting and isolation of colonized infants. and fostering of effective inter- and intrahospital communication. Carbapenem seems to be safe in newborn and is recommended for the treatment of EBLSEs enterobacteriaceae infections (C) 2010 Elsevier Masson SAS All rights reserved