Palladium-catalyzed oxidative carbamoylation of isoquinoline N-oxides with formylamides by means of dual C-H oxidative coupling

被引：31

作者：

Yao, Bo ^{[1
]}

Deng, Chen-Liang ^{[1
]}

Liu, Yan ^{[1
]}

Tang, Ri-Yuan ^{[1
]}

Zhang, Xing-Guo ^{[1
]}

Li, Jin-Heng ^{[2
]}

机构：

[1] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325035, Peoples R China

[2] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 19期

基金：

中国国家自然科学基金;

关键词：

MONOXIDE-FREE AMINOCARBONYLATION; AMIDE BOND FORMATION; FACTOR XA INHIBITORS; ARYL HALIDES; DIRECT ARYLATION; CARBONYLATION REACTIONS; ATMOSPHERIC-PRESSURE; CARBON; AMIDATION; BROMIDES;

D O I：

10.1039/c4cc10140e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new palladium-catalyzed oxidative carbamoylation reaction of isoquinoline N-oxides with formylamides for the synthesis of isoquinoline-1-carboxamides is established. The method represents the first example of the carbamoylation of isoquinoline N-oxides with formylamides to furnish arylamides using the dual C-H oxidation strategy.

引用

页码：4097 / 4100

页数：4

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