Palladium-catalyzed oxidative carbamoylation of isoquinoline N-oxides with formylamides by means of dual C-H oxidative coupling

被引：31
作者：
Yao, Bo [1 ]
Deng, Chen-Liang [1 ]
Liu, Yan [1 ]
Tang, Ri-Yuan [1 ]
Zhang, Xing-Guo [1 ]
Li, Jin-Heng [2 ]
机构：
[1] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325035, Peoples R China
[2] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 19期
基金：
中国国家自然科学基金;
关键词：
MONOXIDE-FREE AMINOCARBONYLATION; AMIDE BOND FORMATION; FACTOR XA INHIBITORS; ARYL HALIDES; DIRECT ARYLATION; CARBONYLATION REACTIONS; ATMOSPHERIC-PRESSURE; CARBON; AMIDATION; BROMIDES;
D O I：
10.1039/c4cc10140e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new palladium-catalyzed oxidative carbamoylation reaction of isoquinoline N-oxides with formylamides for the synthesis of isoquinoline-1-carboxamides is established. The method represents the first example of the carbamoylation of isoquinoline N-oxides with formylamides to furnish arylamides using the dual C-H oxidation strategy.
引用
收藏
页码：4097 / 4100
页数：4
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