Mono- and heterodi-nuclear complexes of aluminium: synthesis, characterization and antifungal activity

Some new types of mononuclear derivatives, AlL(1-4)L(1-4)H (1a-1d) of aluminium were synthesized by the reaction of Al(OPri)(3) and LH2 [XC(NYOH)CHC(R)OH], X = CH3, Y = (CH2)(2,) R = CH3(L1H(2)); X = C6H5, Y = (CH2)(2), R = CH3(L2H(2)); X = CH3, Y = (CH2)(3), R = CH3(L3H(2)); X = C6H5, Y = (CH2)(3), R = CH3(L4H(2)) in 1:2 molar ratio in refluxing benzene. Reactions of AlL(1-4)L(1-4)H with hexamethyldisilazane in 2:1 molar ratio yielded some new ligand bridged heterodinuclear derivatives AlL(1-4)L(1-4)SiMe3 (2a-2d). All these newly synthesized derivatives were characterized by elemental analysis and molecular weight measurements. Tentative structures were proposed on the basis of IR and NMR spectra (H-1, C-13,Al-27 and Si-29) and FAB-mass studies. Schiff base ligands and their mono- and heterodi-nuclear derivatives with aluminium, have been screened for fungicidal activities. These compounds showed significant antifungal activity against Aspergillus niger and A. flavus. Copyright (c) 2007 John Wiley & Sons, Ltd.