Bone Mineral Density in Sjogren Syndrome Patients with and Without Distal Renal Tubular Acidosis

被引:10
作者
Both, Tim [1 ]
Zillikens, M. Carola [2 ]
Hoorn, Ewout J. [3 ]
Zietse, Robert [3 ]
van Laar, Jan A. M. [1 ,4 ]
Dalm, Virgil A. S. H. [1 ,4 ]
van Duijn, Cornelia M. [5 ]
Versnel, Marjan A. [4 ]
Maria, Naomi I. [4 ]
van Hagen, P. Martin [1 ,4 ]
van Daele, Paul L. A. [1 ,4 ]
机构
[1] Dept Internal Med, Div Clin Immunol, POB 2040,Room D-419, NL-3000 CA Rotterdam, Netherlands
[2] Erasmus MC, Dept Endocrinol, Rotterdam, Netherlands
[3] Erasmus MC, Dept Nephrol & Transplantat, Rotterdam, Netherlands
[4] Erasmus MC, Dept Immunol, Rotterdam, Netherlands
[5] Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands
关键词
Bone mineral density; Sjogren syndrome; Distal renal tubular acidosis; Hydroxychloroquine; DEXA scan; SYSTEMIC-LUPUS-ERYTHEMATOSUS; CLASSIFICATION CRITERIA; PREVALENCE; DISEASE; HYDROXYCHLOROQUINE; OSTEOPOROSIS; CALCIUM;
D O I
10.1007/s00223-016-0112-z
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Primary Sjogren's syndrome (pSS) can be complicated by distal renal tubular acidosis (dRTA), which may contribute to low bone mineral density (BMD). Our objective was to evaluate BMD in pSS patients with and without dRTA as compared with healthy controls. BMD of lumbar spine (LS) and femoral neck (FN) was measured in 54 pSS patients and 162 healthy age-and sex-matched controls by dual-energy X-ray absorptiometry (DXA). dRTA was defined as inability to reach urinary pH <5.3 after an ammonium chloride (NH4Cl) test. LS- and FN-BMD were significantly higher in pSS patients compared with controls (1.18 +/- 0.21 g/cm(2) for patients vs. 1.10 +/- 0.18 g/cm(2) for controls, P = 0.008 and 0.9 +/- 0.16 g/cm(2) for patients vs. 0.85 +/- 0.13 g/cm(2) for controls, P = 0.009, respectively). After adjustment for BMI and smoking, the LS- and FN-BMD remained significantly higher. Patients with dRTA (N = 15) did not have a significantly different LS- and FN-BMD compared with those without dRTA (N = 39) after adjustment for BMI, age, and gender. Thirty-seven (69 %) pSS patients were using hydroxychloroquine (HCQ). Unexpectedly, pSS patients had a significantly higher LS- and FN-BMD compared with healthy controls. Patients with dRTA had similar BMD compared with patients without dRTA. We postulate that an explanation for the higher BMD in pSS patients may be the frequent use of HCQ.
引用
收藏
页码:573 / 579
页数:7
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