Encapsulation of CdSe/ZnS quantum dots in poly(ethylene glycol)-Poly(D,L-lactide) micelle for biomedical imaging and detection

被引：35
作者：
Lee, Yong-Kyu
Hong, Suk Min
Kim, Jin Su
Im, Jeong Hyuk
Min, Hyun Su
Subramanyam, Elango
Huh, Kang Moo [1 ]
机构：
[1] Chungnam Natl Univ, Sch Appl Chem & Biol Engn, Taejon 305764, South Korea
[2] Chungju Natl Univ, Dept Chem & Biol Engn, Chungbuk 380702, South Korea
[3] Chungnam Natl Univ, Dept Sci Criminal Invest, Taejon 305764, South Korea
来源：
MACROMOLECULAR RESEARCH | 2007年 / 15卷 / 04期
关键词：
CdSe/ZnS QDs; PEG-PLA diblock copolymer; polymer micelle; encapsulation;
D O I：
10.1007/BF03218795
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Luminescent CdSe/Z,nS QDs, with emission in the red region of the spectrum, were synthesized and encapsulated in poly(ethylene glycol)-poly(D,L-lactide) diblock copolymer micelles, to prepare water-soluble, bio-compatible QD micelles. PEG-PLA dibtock copolymers were synthesized by ring opening polymerization of D,Lactide, in the presence of methoxy PEG as a macroinitiator. QDs were encapsulated with PEG-PLA polymers using a solid dispersion method in chloroform. The resultant polymer micelles, with encapsulated QDs, were characterized using various analytical techniques, such as UV-Vis measurement, light scattering, fluorescence spectroscopy, transmission electron microscopy (TEM) and atomic forced microscopy (AFM). The polymer micelles, with encapsulated QDs, were spherical and showed diameters in the range of 20-150 nm. The encapsulated QDs were highly luminescent, and have high potential for applications in biomedical imaging and detection.
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收藏
页码：330 / 336
页数：7
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