Nutrigenetic Contributions to Dyslipidemia: A Focus on Physiologically Relevant Pathways of Lipid and Lipoprotein Metabolism

被引：26

作者：

Hannon, Bridget A. ^{[1
]}

Khan, Naiman A. ^{[1
,2
]}

Teran-Garcia, Margarita ^{[1
,2
,3
]}

机构：

[1] Univ Illinois, Div Nutr Sci, Urbana, IL 61801 USA

[2] Univ Illinois, Dept Kinesiol & Community Hlth, Urbana, IL 61801 USA

[3] Univ Illinois, Carle Illinois Coll Med, Dept Human Dev & Family Studies, Cooperat Extens, Urbana, IL 61801 USA

来源：

NUTRIENTS | 2018年 / 10卷 / 10期

基金：

美国食品与农业研究所;

关键词：

dyslipidemia; nutrigenetics; lipids; DIETARY FATTY-ACIDS; SINGLE NUCLEOTIDE POLYMORPHISMS; HDL-CHOLESTEROL CONCENTRATIONS; MEDITERRANEAN DIET; CARDIOVASCULAR-DISEASE; HEPATIC LIPASE; WEIGHT-LOSS; MYOCARDIAL-INFARCTION; COMMON POLYMORPHISM; NUTRITION RESEARCH;

D O I：

10.3390/nu10101404

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Cardiovascular disease (CVD) remains the number one cause of death worldwide, and dyslipidemia is a major predictor of CVD mortality. Elevated lipid concentrations are the result of multiple genetic and environmental factors. Over 150 genetic loci have been associated with blood lipid levels. However, not all variants are present in pathways relevant to the pathophysiology of dyslipidemia. The study of these physiologically relevant variants can provide mechanistic understanding of dyslipidemia and identify potential novel therapeutic targets. Additionally, dietary fatty acids have been evidenced to exert both positive and negative effects on lipid profiles. The metabolism of both dietary and endogenously synthesized lipids can be affected by individual genetic variation to produce elevated lipid concentrations. This review will explore the genetic, dietary, and nutrigenetic contributions to dyslipidemia.

引用

页数：17

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