Advanced fibrosis associates with atherosclerosis in subjects with nonalcoholic fatty liver disease

被引：64

作者：

Chen, Ying ^{[1
,2
]}

Xu, Min ^{[1
,2
]}

Wang, Tiange ^{[1
,2
]}

Sun, Jichao ^{[1
,2
]}

Sun, Wanwan ^{[1
,2
]}

Xu, Baihui ^{[1
,2
]}

Huang, Xiaolin ^{[1
,2
]}

Xu, Yu ^{[1
,2
]}

Lu, Jieli ^{[1
,2
]}

Li, Xiaoying ^{[1
,2
]}

Wang, Weiqing ^{[1
,2
]}

Bi, Yufang ^{[1
,2
]}

Ning, Guang ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, Minist Hlth,Collaborat Innovat Ctr Syst Biomed, State Key Lab Med Genom,Key Lab Endocrine & Metab, Rui Jin Hosp,Sch Med,E Inst Shanghai Univ,Natl Cl, Shanghai 200025, Peoples R China

[2] Shanghai Jiao Tong Univ, Shanghai Clin Ctr Endocrine & Metab Dis, Shanghai Inst Endocrine & Metab Dis,Dept Endocrin, Dept Endocrine & Metab Dis,Rui Jin Hosp,Sch Med, Shanghai 200025, Peoples R China

来源：

ATHEROSCLEROSIS | 2015年 / 241卷 / 01期

基金：

中国国家自然科学基金; 国家高技术研究发展计划(863计划);

关键词：

Nonalcoholic fatty liver disease; Fibrosis score; Atherosclerosis; Carotid intima-media thickness; Carotid plaque; Brachial-ankle pulse wave velocity; INTIMA-MEDIA THICKNESS; TERM-FOLLOW-UP; LONG-TERM; AMERICAN ASSOCIATION; PRACTICE GUIDELINE; DIAGNOSIS; RISK; MANAGEMENT; STEATOSIS; NAFLD;

D O I：

10.1016/j.atherosclerosis.2015.05.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: Nonalcoholic fatty liver (NAFLD) with advanced fibrosis usually has a deteriorated prognosis, which was mainly attributed to cardiovascular cause. We investigated whether advanced fibrosis assessed by noninvasive fibrosis markers was associated with subclinical atherosclerosis in NAFLD patients. Methods: A total of 2550 participants with ultrasound confirmed NAFLD from a community based population study were included in the present analysis. NAFLD fibrosis score (NFS) derived from available parameters was calculated to assess severity of fibrosis of the NAFLD patients. The NAFLD patients with a NFS > 0.676 indicated of presence of advanced fibrosis. The carotid intima-media thickness (CIMT), carotid plaques and brachial-ankle pulse wave velocity (ba-PWV) were used as the indicators of early atherosclerosis. Results: NAFLD patients with advanced fibrosis had higher CIMT and ba-PWV, compared with those without fibrosis (CIMT: 0.65 versus 0.57 mm; ba-PWV: 1884 versus 1535 cm/s, both p < 0.0001). Participants with advanced fibrosis were more likely to have higher homeostasis model assessment of insulin resistance index (HOMA_IR, 3.28 versus 2.45, p < 0.0001). After adjusting the confounders, participants with advanced fibrosis associated with 1.98-folds increased risk for elevated CIMT, 2.28-folds increased risk for present carotid plaque and 2.68-folds increased risk for arterial stiffness, respectively, as compared to participants without fibrosis. After further adjustment for HOMA_IR, the positive associations did not appreciably change. Conclusion: Advanced fibrosis indicated by NFS was positively associated with CIMT, presence of carotid plaque and arterial stiffness in the NAFLD patients, independent of conventional cardiometabolic risk factors and insulin resistance. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

引用

页码：145 / 150

页数：6

共 29 条

[1] The natural history of nonalcoholic fatty liver disease: A population-based cohort study [J].