Chemical and light triggering of peptide networks under partial thermodynamic control

被引：41

作者：

Dadon, Zehavit ^{[1
]}

Samiappan, Manickasundaram ^{[1
]}

Wagner, Nathaniel ^{[1
]}

Ashkenasy, Gonen ^{[1
]}

机构：

[1] Ben Gurion Univ Negev, Dept Chem, IL-84105 Beer Sheva, Israel

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 10期

基金：

欧洲研究理事会;

关键词：

DYNAMIC COMBINATORIAL LIBRARIES; SYSTEMS CHEMISTRY; SELF-REPLICATION; MOLECULAR NETWORKS; CATALYSIS;

D O I：

10.1039/c1cc14301h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The kinetics of novel dynamic libraries that operate via reversible replication is described. In these systems, selective product formation is governed by peptides autocatalytic efficiency and by differences in their unfolding stability. We suggest ways to significantly alter the network behavior by chemical inputs (templates) or physical triggers (light).

引用

页码：1419 / 1421

页数：3

共 29 条

[1] Boolean logic functions of a synthetic peptide network [J].

Ashkenasy, G ;

Ghadiri, MR .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (36) :11140-11141

[2] Design of a directed molecular network [J].

Ashkenasy, G ;

Jagasia, R ;

Yadav, M ;

Ghadiri, MR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (30) :10872-10877

[3] Building Logic into Peptide Networks: Bottom-Up and Top-Down [J].

Ashkenasy, Gonen ;

Dadon, Zehavit ;

Alesebi, Samaa ;

Wagner, Nathaniel ;

Ashkenasy, Nurit .

ISRAEL JOURNAL OF CHEMISTRY, 2011, 51 (01) :106-117

[4]

Bhat VT, 2010, NAT CHEM, V2, P490, DOI [10.1038/NCHEM.658, 10.1038/nchem.658]

[5] Mechanosensitive Self-Replication Driven by Self-Organization [J].

Carnall, Jacqui M. A. ;

Waudby, Christopher A. ;

Belenguer, Ana M. ;

Stuart, Marc C. A. ;

Peyralans, Jerome J. -P. ;

Otto, Sijbren .

SCIENCE, 2010, 327 (5972) :1502-1506

[6] Dynamic combinatorial chemistry [J].

Corbett, Peter T. ;

Leclaire, Julien ;

Vial, Laurent ;

West, Kevin R. ;

Wietor, Jean-Luc ;

Sanders, Jeremy K. M. ;

Otto, Sijbren .

CHEMICAL REVIEWS, 2006, 106 (09) :3652-3711

[7] The road to non-enzymatic molecular networks [J].

Dadon, Zehavit ;

Wagner, Nathaniel ;

Ashkenasy, Gonen .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2008, 47 (33) :6128-6136

[8] Light-Induced Peptide Replication Controls Logic Operations in Small Networks [J].

Dadon, Zehavit ;

Samiappan, Manickasundaram ;

Safranchik, Eliya Y. ;

Ashkenasy, Gonen .

CHEMISTRY-A EUROPEAN JOURNAL, 2010, 16 (40) :12096-12099

[9] Manipulating Replication Processes within a Dynamic Covalent Framework [J].

del Amo, Vicente ;

Slawin, Alexandra M. Z. ;

Philp, Douglas .

ORGANIC LETTERS, 2008, 10 (20) :4589-4592

[10] Integrating Replication-Based Selection Strategies in Dynamic Covalent Systems [J].

del Amo, Vicente ;

Philp, Douglas .

CHEMISTRY-A EUROPEAN JOURNAL, 2010, 16 (45) :13304-13318

← 1 2 3 →