Dual-Responsive Boronate Crosslinked Micelles for Targeted Drug Delivery

被引：71
|
作者：
Chen, Weixuan [1 ,2 ]
Cheng, Yunfeng [1 ,2 ]
Wang, Binghe [1 ,2 ]
机构：
[1] Georgia State Univ, Dept Chem, Ctr Biotechnol & Drug Design, Atlanta, GA 30302 USA
[2] Georgia State Univ, Ctr Diagnost & Therapeut, Atlanta, GA 30302 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 22期
关键词：
boron; drug delivery; FRET; micelles; nanotechnology; POLYMERIC MICELLES; PH; NANOCARRIERS; RELEASE;
D O I：
10.1002/anie.201201179
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Controlled trigger finger: A novel class of micelles for targeted drug delivery was developed. The strategy relies on boronic acid-diol interactions as a way of accessing crosslinked micelles having improved stability (see scheme) and quick payload release in response to low pHenvironments or diol addition. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：5293 / 5295
页数：3
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