Dual-Responsive Boronate Crosslinked Micelles for Targeted Drug Delivery

被引：72

作者：

Chen, Weixuan ^{[1
,2
]}

Cheng, Yunfeng ^{[1
,2
]}

Wang, Binghe ^{[1
,2
]}

机构：

[1] Georgia State Univ, Dept Chem, Ctr Biotechnol & Drug Design, Atlanta, GA 30302 USA

[2] Georgia State Univ, Ctr Diagnost & Therapeut, Atlanta, GA 30302 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 22期

关键词：

boron; drug delivery; FRET; micelles; nanotechnology; POLYMERIC MICELLES; PH; NANOCARRIERS; RELEASE;

D O I：

10.1002/anie.201201179

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Controlled trigger finger: A novel class of micelles for targeted drug delivery was developed. The strategy relies on boronic acid-diol interactions as a way of accessing crosslinked micelles having improved stability (see scheme) and quick payload release in response to low pHenvironments or diol addition. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：5293 / 5295

页数：3

共 25 条

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[2] In vivo antitumor activity of the folate-conjugated pH-Sensitive polymeric micelle selectively releasing adriamycin in the intracellular acidic compartments [J].