Enantioselective butylation of aliphatic aldehydes by mixed chiral lithium amide n-BuLi dimers

被引：52

作者：

Arvidsson, PI ^{[1
]}

Davidsson, O ^{[1
]}

Hilmersson, G ^{[1
]}

机构：

[1] Univ Gothenburg, Dept Chem, S-41296 Gothenburg, Sweden

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 03期

关键词：

D O I：

10.1016/S0957-4166(99)00033-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The enantioselective butylation of aliphatic aldehydes with mixtures of n-butyllithium and chiral lithium amides in a diethyl ether-dimethoxymethane solvent mixture is described. Enantiomeric excesses ranging from 91 to 98.5% were observed for several aliphatic alcohols. The asymmetric butylation of the prochiral aldehydes proceeds much faster by the mixed lithium amide/n-BuLi complexes than by tetrameric n-BuLi. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：527 / 534

页数：8

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