Indole melatonin agonists and antagonists derived by shifting the melatonin side chain from the C-3 to the N-1 or to the C-2 indole position

被引：0

作者：

Tarzia, G ^{[1
]}

Diamantini, G ^{[1
]}

Spadoni, G ^{[1
]}

机构：

[1] Univ Urbino, Ist Chim Farmaceut & Tossicol, I-61029 Urbino, Italy

来源：

BIOLOGICAL SIGNALS AND RECEPTORS | 1999年 / 8卷 / 1-2期

关键词：

melatonin analogs; agonists; antagonists;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This article reviews our efforts in the development of indole melatonin (MLT) agonist and antagonist compounds, Evidence is presented which indicates that high-affinity melatonergic agonists were obtained by shifting the MLT amido side chain from the C-3 to the N-1 indole position, Conversely, by moving the side chain from the C-3 to the C-2 indole position it is possible to produce MLT antagonist compounds.

引用

页码：24 / 31

页数：8

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