Free radical activity of mineral fibres containing adsorbed ferritin:: Detection using supercoiled DNA

被引：6
作者：
Areán, CO
Barceló, F
机构：
[1] Univ Islas Baleares, Fac Ciencias, Palma de Mallorca, Spain
[2] Univ Turin, Dipartimento Chim Inorgan Chim Fis & Chim Mat, Turin, Italy
来源：
RESEARCH ON CHEMICAL INTERMEDIATES | 1999年 / 25卷 / 02期
关键词：
D O I：
10.1163/156856799X00284
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Mammalian ferritin was found to adsorb strongly, from aqueous solutions, onto the amphibole group minerals amosite and crocidolite. The mineral fibres containing adsorbed ferritin were found to show high free-radical activity leading to radical damage to DNA, which was quantified by electrophoretic assays with the pCSI2 plasmid. The results are discussed in terms of possible implications in the pathogenicity of asbestos bodies which are formed in vivo after inhaling mineral fibres, and which often contain endogenous ferritin in their coatings.
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页码：177 / 185
页数：9
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