Formal C-H/C-I Metathesis: Site-Selective C-H Iodination of 2-Aryl Benzoic Acid Derivatives Using Aryl Iodide

被引：10

作者：

Gao, Zezhong ^{[1
,2
]}

Wang, Hang ^{[2
]}

Zhou, Chunlin ^{[2
]}

Wang, Ning ^{[2
]}

Li, Shangda ^{[2
]}

Li, Gang ^{[2
,3
]}

机构：

[1] Fuzhou Univ, Coll Chem, Fuzhou 350002, Fujian, Peoples R China

[2] Chinese Acad Sci, Fujian Inst Res Struct Matter, Key Lab Coal Ethylene Glycol & Its Related Techno, Fuzhou 350002, Fujian, Peoples R China

[3] Shanghai Jiao Tong Univ, Frontiers Sci Ctr Transformat Mol, Shanghai 200240, Peoples R China

来源：

ORGANIC LETTERS | 2022年 / 24卷 / 22期

关键词：

CATALYZED ORTHO-HALOGENATION; REDUCTIVE ELIMINATION; CARBOXYLIC-ACIDS; FUNCTIONALIZATION; BONDS; HALIDES; CYCLIZATION; CLEAVAGE; EXCHANGE; ARENE;

D O I：

10.1021/acs.orglett.2c01224

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

C-H functionalization via functional group metathesis is extremely rare. A protocol of remote site-selective C-H iodination of 2-aryl benzoic acid derivatives via formal C(sp(2))-H/C(sp(2))-I metathesis using readily available 1-iodo-4-methoxy-2-nitrobenzene as the mild iodinating reagent was reported herein. A range of 2-aryl benzoic acid derivatives including 2-(naphthalen-1-yl)benzoic acids and [1,1'-binaphthalene]-2-carboxylic acids were iodinated under mild conditions to give valuable iodinated products in a site- and chemo-selective fashion.

引用

页码：3926 / 3931

页数：6

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