Obesity: The role of hypothalamic AMP-activated protein kinase in body weight regulation

被引：50

作者：

Lee, WJ ^{[1
]}

Koh, EH ^{[1
]}

Won, JH ^{[1
]}

Kim, MS ^{[1
]}

Park, JY ^{[1
]}

Lee, KU ^{[1
]}

机构：

[1] Univ Ulsan, Coll Med, Med Ctr, Dept Internal Med, Seoul 138600, South Korea

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2005年 / 37卷 / 11期

关键词：

obesity; hypothalamus; AMPK; alpha-lipoic acid;

D O I：

10.1016/j.biocel.2005.06.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Obesity is rapidly increasing and is of great public health concern worldwide. Although there have been remarkable developments in obesity research over the past 10 years, the molecular mechanism of obesity is still not completely understood. Body weight results from the balance between food intake and energy expenditure. Recent studies have found that hypothalamic AMP-activated protein kinase plays a key role in regulating these processes. Leptin, insulin, glucose and alpha-lipoic acid have been shown to reduce food intake by lowering hypothalamic AMP-activated protein kinase activity, whereas ghrelin and glucose depletion increase food intake by increasing hypothalamic AMP-activated protein kinase activity. In addition, this enzyme plays a role in the central regulation of energy expenditure. These findings indicate that hypothalamic AMP-activated protein kinase is an important signal molecule, which integrates nutritional and hormonal signals and modulates feeding behavior and energy expenditure. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：2254 / 2259

页数：6

共 21 条

[1] AMP-activated protein kinase plays a role in the control of food intake [J].

Andersson, U ;

Filipsson, K ;

Abbott, CR ;

Woods, A ;

Smith, K ;

Bloom, SR ;

Carling, D ;

Small, CJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (13) :12005-12008

[2] βAR signaling required for diet-induced thermogenesis and obesity resistance [J].

Bachman, ES ;

Dhillon, H ;

Zhang, CY ;

Cinti, S ;

Bianco, AC ;

Kobilka, BK ;

Lowell, BB .

SCIENCE, 2002, 297 (5582) :843-845

[3] Over-expression of sterol-regulatory-element-binding protein-1c (SREBP1c) in rat pancreatic islets induces lipogenesis and decreases glucose-stimulated insulin release:: modulation by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) [J].

Diraison, F ;

Parton, L ;

Ferré, P ;

Foufelle, F ;

Briscoe, CP ;

Leclerc, I ;

Rutter, GA .

BIOCHEMICAL JOURNAL, 2004, 378 :769-778

[4] Obesity wars: Molecular progress confronts an expanding epidemic [J].

Flier, JS .

CELL, 2004, 116 (02) :337-350

[5] Update on adipocyte hormones - Regulation of energy balance and carbohydrate/lipid metabolism [J].

Havel, PJ .

DIABETES, 2004, 53 :S143-S151

[6] AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism [J].

Kahn, BB ;

Alquier, T ;

Carling, D ;

Hardie, DG .

CELL METABOLISM, 2005, 1 (01) :15-25

[7] AICA-riboside induces apoptosis of pancreatic beta cells through stimulation of AMP-activated protein kinase [J].

Kefas, BA ;

Heimberg, H ;

Vaulont, S ;

Meisse, D ;

Hue, L ;

Pipeleers, D ;

Casteele, M .

DIABETOLOGIA, 2003, 46 (02) :250-254

[8] Anti-obesity effects of α-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase [J].

Kim, MS ;

Park, JY ;

Namkoong, C ;

Jang, PG ;

Ryu, JW ;

Song, HS ;

Yun, JY ;

Namgoong, IS ;

Ha, J ;

Park, IS ;

Lee, IK ;

Viollet, B ;

Youn, JH ;

Lee, HK ;

Lee, KU .

NATURE MEDICINE, 2004, 10 (07) :727-733

[9] α-lipoic acid increases insulin sensitivity by activating AMPK in skeletal muscle [J].

Lee, WJ ;

Song, KH ;

Koh, EH ;

Won, JC ;

Kim, HS ;

Park, HS ;

Kim, MS ;

Kim, SW ;

Lee, KU ;

Park, JY .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 332 (03) :885-891

[10] Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors [J].

Loftus, TM ;

Jaworsky, DE ;

Frehywot, GL ;

Townsend, CA ;

Ronnett, GV ;

Lane, MD ;

Kuhajda, FP .

SCIENCE, 2000, 288 (5475) :2379-2381

← 1 2 3 →