FOXM1: From cancer initiation to progression and treatment

被引：341

作者：

Koo, Chuay-Yeng ^{[1
]}

Muir, Kyle W. ^{[1
]}

Lam, Eric W. -F. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Surg & Canc, London W12 0NN, England

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS | 2012年 / 1819卷 / 01期

关键词：

FOXM1; Chemotherapy; Cancer; Function; Regulation; M1 TRANSCRIPTION FACTOR; BREAST-CANCER; CELL-PROLIFERATION; OXIDATIVE STRESS; UP-REGULATION; HEPATOCELLULAR CARCINOMAS; NUCLEAR TRANSLOCATION; MULTIDRUG-RESISTANCE; DOWNSTREAM TARGET; HEPATOCYTE ENTRY;

D O I：

10.1016/j.bbagrm.2011.09.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Forkhead box protein M1 (FOXM1) transcription factor is a regulator of myriad biological processes, including cell proliferation, cell cycle progression, cell differentiation, DNA damage repair, tissue homeostasis, angiogenesis and apoptosis. Elevated FOXM1 expression is found in cancers of the liver, prostate, brain, breast, lung, colon, pancreas, skin, cervix, ovary, mouth, blood and nervous system, suggesting it has an integral role in tumorigenesis. Recent research findings also place FOXM1 at the centre of cancer progression and drug sensitivity. In this review the involvement of FOXM1 in various aspects of cancer, in particular its role and regulation within the context of cancer initiation, progression, and cancer drug response, will be summarised and discussed. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：28 / 37

页数：10

共 116 条

[11] Gefitinib therapy for non-small cell lung cancer [J].

Birnbaum A. ;

Ready N. .

Current Treatment Options in Oncology, 2005, 6 (1) :75-81

[12]

Brosens JJ, 2009, ADV EXP MED BIOL, V665, P227

[13]

BRUNNER N, 1989, CANCER CELL-MON REV, V1, P81

[14] FoxM1 Mediates Resistance to Herceptin and Paclitaxel [J].

Carr, Janai R. ;

Park, Hyun Jung ;

Wang, Zebin ;

Kiefer, Megan M. ;

Raychaudhuri, Pradip .

CANCER RESEARCH, 2010, 70 (12) :5054-5063

[15] Small-molecule inhibitors of the human epidermal receptor family [J].

Carter, Corey A. ;

Kelly, Ronan J. ;

Giaccone, Giuseppe .

EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2009, 18 (12) :1829-1842

[16] Over-expression of FOXM1 transcription factor is associated with cervical cancer progression and pathogenesis [J].

Chan, D. W. ;

Yu, S. Y. M. ;

Chiu, P. M. ;

Yao, K. M. ;

Liu, V. W. S. ;

Cheung, A. N. Y. ;

Ngan, H. Y. S. .

JOURNAL OF PATHOLOGY, 2008, 215 (03) :245-252

[17] Gene expression profiles of prostate cancer reveal involvement of multiple molecular pathways in the metastatic process [J].

Chandran, Uma R. ;

Ma, Changqing ;

Dhir, Rajiv ;

Bisceglia, Michelle ;

Lyons-Weiler, Maureen ;

Liang, Wenjing ;

Michalopoulos, George ;

Becich, Michael ;

Monzon, Federico A. .

BMC CANCER, 2007, 7 (1)

[18]

Ciardiello F, 2001, CLIN CANCER RES, V7, P2958

[19] A genomic view of estrogen actions in human breast cancer cells by expression profiling of the hormone-responsive transcriptome [J].

Cicatiello, L ;

Scafoglio, C ;

Altucci, L ;

Cancemi, M ;

Natoli, G ;

Facchiano, A ;

Iazzetti, G ;

Calogero, R ;

Biglia, N ;

De Bortoli, M ;

Sfiligoi, C ;

Sismondi, P ;

Bresciani, F ;

Weisz, A .

JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2004, 32 (03) :719-775

[20] Trans-Platinum Complexes in Cancer Therapy [J].

Coluccia, Mauro ;

Natile, Giovanni .

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2007, 7 (01) :111-123

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