Postnatal-related changes in the size and total number of neurons in the caudal mesenteric ganglion of dogs: Total number of neurons can be predicted from body weight and ganglion volume

被引:15
作者
Gagliardo, KM
Balieiro, ACDC
Ribeiro, AACM
机构
[1] Univ Sao Paulo, Fac Med Vet & Zootecnia, Dept Cirurgia, Coll Vet Med, BR-05508000 Sao Paulo, Brazil
[2] Univ Sao Paulo, Coll Anim Sci & Food Engn, Dept Basic Sci, Pirassununga, Brazil
[3] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, Sao Paulo, Brazil
来源
ANATOMICAL RECORD PART A-DISCOVERIES IN MOLECULAR CELLULAR AND EVOLUTIONARY BIOLOGY | 2005年 / 286A卷 / 02期
关键词
stereology; disector; caudal mesenteric ganglion; dogs; middle aging;
D O I
10.1002/ar.a.20233
中图分类号
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号
100101 ;
摘要
Aging is mostly characterized by a progressive decline of neuronal function that involves both the central and the peripheral nervous system. The aging process is accompanied by changes in either the number or the size of neurons. However, these data are controversial and not very well known in the sympathetic ganglia of large mammals. Hence, the present investigation aimed to study the dog's caudal mesenteric ganglion (CMG) in three different periods of postnatal development, searching for qualitative and quantitative alterations. The CMG is responsible for the large intestine, internal anal sphincter, and partially the urogenital system innervations. Nine dead male dogs from the Veterinary Hospital of the College of Veterinary Medicine at University of Sao Paulo were divided into three well-defined age groups (1-2 months old, 1-2 years old, and 5-10 years old). The stereological study was pursued using the physical disector method combined to the Cavalieri principle. The postnatal development was accompanied by an increase in the nonneuronal tissue amount and in ganglion volume. Additionally, the total number of neurons also increased during aging (from 70,140 to 1,204,516), although the neuronal density showed an opposite trend (from 29,911 to 11,500 mm(-3)). Due to the interrelation between either body weight or ganglion volume and aging in the dogs investigated in this study, it was possible to predict the total number of neurons in CMG using both body weight and ganglion volume in an attempt to verify whether or not size and total number of neurons are both allometrically and aging ruled, i.e., if either the animal's body weight and ganglion volume or aging influence these parameters. The prediction of the total number of neurons was very close to the initially estimated values. (C) 2005 Wiley-Liss, Inc.
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页码:917 / 929
页数:13
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