Measurement of the hemoglobin oxygen saturation level with spectroscopic spectral-domain optical coherence tomography

被引：47

作者：

Lu, Chih-Wei ^{[1
]}

Lee, Cheng-Kuang ^{[1
]}

Tsai, Meng-Tsan ^{[1
]}

Wang, Yih-Ming ^{[1
]}

Yang, C. C. ^{[1
]}

机构：

[1] Natl Taiwan Univ, Inst Photon & Optoelect, Sect 4, Taipei 10764, Taiwan

来源：

OPTICS LETTERS | 2008年 / 33卷 / 05期

关键词：

Absorption - Optical resolving power - Optical tomography - Real time systems - Saturation (materials composition) - Wavelength;

D O I：

10.1364/OL.33.000416

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We report the measurement of the hemoglobin (Hb) oxygen saturation level in human blood with a spectroscopic spectral-domain optical coherence tomography (SSD-OCT) system based on the crossover behavior of Hb and oxyhemoglobin (HbO(2)) absorption coefficients around 800 nm. By calculating the ratio of the exponential decay constant of A-mode scan signal in the long-wavelength range (>800 nm) over that in the short-wavelength range (<800 nm), the relative oxygen saturation level of Hb can be calibrated. Such a relative level can be used for practical diagnosis application after a golden standard is built by comparing the variation of the OCT result with that of a conventional method, such as the use of a blood gas analyzer. In our experiment, the variation curve based on the SSD-OCT measurement, which has the advantages of noninvasive, real-time, and high-resolution measurements, is coincident with that of using a commercial blood gas analyzer. (C) 2008 Optical Society of America.

引用

页码：416 / 418

页数：3

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