Clinical Implications of Increased Nogo-B Levels in Patients With Acute Coronary Syndromes and Stable Angina Pectoris

被引：2
作者：
Gao, Beibei [1 ,3 ]
Xu, Yizhou [1 ,3 ]
Leng, Jianhang [2 ,3 ]
Wang, Keyi [2 ,3 ]
Xia, Bohou [4 ]
Huang, Jinyu [1 ,3 ]
机构：
[1] Nanjing Med Univ, Hangzhou Peoples Hosp 1, Dept Cardiol, Hangzhou 310006, Zhejiang, Peoples R China
[2] Nanjing Med Univ, Hangzhou Peoples Hosp 1, Cent Lab, Hangzhou 310006, Zhejiang, Peoples R China
[3] Nanjing Med Univ, Affiliated Hangzhou Hosp, Hangzhou 310006, Zhejiang, Peoples R China
[4] Hunan Univ Tradit Chinese Med, Dept Pharm, Changsha, Hunan, Peoples R China
来源：
INTERNATIONAL HEART JOURNAL | 2015年 / 56卷 / 03期
关键词：
Plasma Nogo-B; Coronary artery disease; RECEPTOR; CELLS;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Although the relationship between arteriosclerosis and inflammatory response has been recognized in recent years, little is known regarding the change in plasma Nogo-B in coronary artery disease (CAD). Thus, we investigated the expression levels of Nogo-B in CAD patients and examined this relation with disease stages. We recruited 92 CA]) patients including 64 with acute coronary syndromes (ACS) and 28 with stable angina pectoris (SAP) cases and 28 healthy controls. The serum concentrations of Nogo-B were measured by enzyme-linked immunosorbent assay (ELISA). The plasma Nogo-B level was significantly higher in patients with ACS and SAP when compared with the healthy controls (both P < 0.05). Multivariate logistic regression analysis revealed that the level of Nogo-B was associated with CAD (odds ratio 1.006, 95% CI: 1.000-1.013, P < 0.05). In conclusion, an increased plasma Nogo-B level may be associated with CAD.
引用
收藏
页码：341 / 344
页数：4
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