Role of the CXCL13/CXCR5 Axis in Autoimmune Diseases

被引：94
作者：
Pan, Zijian [1 ,2 ]
Zhu, Tong [1 ,2 ]
Liu, Yanjun [1 ]
Zhang, Nannan [1 ]
机构：
[1] Sichuan Univ, West China Univ Hosp 2, Natl Ctr Birth Defect Monitoring, Key Lab Birth Defects & Related Dis Women & Child, Chengdu, Peoples R China
[2] Sichuan Univ, West China Hosp Stomatol, Chengdu, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷
基金：
中国国家自然科学基金;
关键词：
CXCL13; CXCR5; chemokine; autoimmunity; therapeutic target; HELPER T-CELLS; ECTOPIC LYMPHOID NEOGENESIS; ATTRACTING CHEMOKINE-1 CXCL13; B-CELL; RHEUMATOID-ARTHRITIS; MULTIPLE-SCLEROSIS; GERMINAL CENTER; CHEMOATTRACTANT CXCL13; SJOGRENS-SYNDROME; MENINGEAL INFLAMMATION;
D O I：
10.3389/fimmu.2022.850998
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
CXCL13 is a B-cell chemokine produced mainly by mesenchymal lymphoid tissue organizer cells, follicular dendritic cells, and human T follicular helper cells. By binding to its receptor, CXCR5, CXCL13 plays an important role in lymphoid neogenesis, lymphoid organization, and immune responses. Recent studies have found that CXCL13 and its receptor CXCR5 are implicated in the pathogenesis of several autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, primary Sjogren's syndrome, myasthenia gravis, and inflammatory bowel disease. In this review, we discuss the biological features of CXCL13 and CXCR5 and the recent findings on the pathogenic roles of the CXCL13/CXCR5 axis in autoimmune diseases. Furthermore, we discuss the potential role of CXCL13 as a disease biomarker and therapeutic target in autoimmune diseases.
引用
收藏
页数：19
相关论文
共 50 条
[21]   Effects of CXCL13 inhibition on lymphoid follicles in models of autoimmune disease [J].
Finch, Donna K. ;
Ettinger, Rachel ;
Karnell, Jodi L. ;
Herbst, Ronald ;
Sleeman, Matthew A. .
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2013, 43 (05) :501-509
[22]   Chemokine CXCL13 mediates orofacial neuropathic pain via CXCR5/ERK pathway in the trigeminal ganglion of mice [J].
Zhang, Qian ;
Cao, De-Li ;
Zhang, Zhi-Jun ;
Jiang, Bao-Chun ;
Gao, Yong-Jing .
JOURNAL OF NEUROINFLAMMATION, 2016, 13
[23]   CXCL13/CXCR5 Interaction Facilitates VCAM-1-Dependent Migration in Human Osteosarcoma [J].
Liu, Ju-Fang ;
Lee, Chiang-Wen ;
Lin, Chih-Yang ;
Chao, Chia-Chia ;
Chang, Tsung-Ming ;
Han, Chien-Kuo ;
Huang, Yuan-Li ;
Fong, Yi-Chin ;
Tang, Chih-Hsin .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (17) :1-13
[24]   The Role of the CXCL12/CXCR4/ACKR3 Axis in Autoimmune Diseases [J].
Garcia-Cuesta, Eva M. ;
Santiago, Cesar A. ;
Vallejo-Diaz, Jesus ;
Juarranz, Yasmina ;
Miguel Rodriguez-Frade, Jose ;
Mellado, Mario .
FRONTIERS IN ENDOCRINOLOGY, 2019, 10
[25]   Genetic polymorphisms of CXCR5 and CXCL13 are associated with non-responsiveness to the hepatitis B vaccine [J].
Duan, Zhaojun ;
Chen, Xiangmei ;
Liang, Zhenglun ;
Zeng, Ying ;
Zhu, Fengcai ;
Long, Lu ;
McCrae, Malcolm A. ;
Zhuang, Hui ;
Shen, Tao ;
Lu, Fengmin .
VACCINE, 2014, 32 (41) :5316-5322
[26]   Regulative role of the CXCL13-CXCR5 axis in the tumor microenvironment [J].
Tan, Ping ;
Shi, Ming ;
Lai, Li ;
Tang, Zhuang ;
Xie, Nan ;
Xu, Hang ;
Wei, Qiang ;
Zhang, Xiaoyu ;
Yang, Lu ;
Wu, Lily .
PRECISION CLINICAL MEDICINE, 2018, 1 (01) :49-56
[27]   Single-cell profiling reveals the importance of CXCL13/CXCR5 axis biology in lymphocyte-rich classic Hodgkin lymphoma [J].
Aoki, Tomohiro ;
Chong, Lauren C. ;
Takata, Katsuyoshi ;
Milne, Katy ;
Marshall, Ashley ;
Chavez, Elizabeth A. ;
Miyata-Takata, Tomoko ;
Ben-Neriah, Susana ;
Unrau, Doria ;
Telenius, Adele ;
Boyle, Merrill ;
Weng, Andrew P. ;
Savage, Kerry J. ;
Scott, David W. ;
Farinha, Pedro ;
Shah, Sohrab P. ;
Nelson, Brad H. ;
Steidl, Christian .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 118 (41)
[28]   Altered Expression of CXCL13 and CXCR5 in Intractable Temporal Lobe Epilepsy Patients and Pilocarpine-Induced Epileptic Rats [J].
Li, Ruohan ;
Ma, Limin ;
Huang, Hao ;
Ou, Shu ;
Yuan, Jinxian ;
Xu, Tao ;
Yu, Xinyuan ;
Liu, Xi ;
Yang, Juan ;
Chen, Yangmei ;
Peng, Xi .
NEUROCHEMICAL RESEARCH, 2017, 42 (02) :526-540
[29]   The CXCL13/CXCR5-chemokine axis in neuroinflammation: evidence of CXCR5+CD4 T cell recruitment to CSF [J].
Harrer, Christine ;
Otto, Ferdinand ;
Pilz, Georg ;
Haschke-Becher, Elisabeth ;
Trinka, Eugen ;
Hitzl, Wolfgang ;
Wipfler, Peter ;
Harrer, Andrea .
FLUIDS AND BARRIERS OF THE CNS, 2021, 18 (01)
[30]   Expression features of CXCR5 and its ligand, CXCL13 associated with poor prognosis of advanced colorectal cancer [J].
Qi, X. -W. ;
Xia, S. -H. ;
Yin, Y. ;
Jin, L. -F. ;
Pu, Y. ;
Hua, D. ;
Wu, H. -R. .
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2014, 18 (13) :1916-1924
12345