Surface-induced reversible addition-fragmentation chain-transfer (RAFT) polymerization on magnetic nanoparticles to resist nonspecific adsorption of proteins

被引：9

作者：

Wang, Shixing ^{[1
,2
]}

Zhou, Yang ^{[1
]}

Peng, Jinghui ^{[1
]}

Niu, Hua ^{[2
]}

Zhang, Xuezhong ^{[2
]}

Yang, Fan ^{[2
]}

机构：

[1] Kunming Univ Sci & Technol, Fac Met & Energy Engn, Kunming 650093, Peoples R China

[2] Yunnan Inst Prod Qual Supervis & Inspect, Kunming 650223, Peoples R China

来源：

CHEMICAL ENGINEERING JOURNAL | 2011年 / 173卷 / 03期

关键词：

Magnetic nanoparticles; Surface modification; Graft polymerization; Protein adsorption; TRANSFER RADICAL POLYMERIZATION; SUPERPARAMAGNETIC NANOPARTICLES; FE3O4; NANOPARTICLES; DIBLOCK COPOLYMERS; POLY(N-ISOPROPYLACRYLAMIDE); FUNCTIONALIZATION; DISPERSIONS; HYBRIDS; AGENTS;

D O I：

10.1016/j.cej.2011.08.067

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Surface-induced reversible addition-fragmentation chain-transfer (RAFT) polymerization was carried out to grow diblock polymer brush of poly(ethylene glycol) monomethacrylate and N-isopropylacrylamide on magnetic nanoparticles (MNPs). After the chain transfer agent group for RAFT polymerization was chemically bound on the surfaces of MNPs, poly(N-isopropylacrylamide) was grown from the surfaces of MNPs via RAFT polymerization. The initial homopolymer on MNPs was used as the chain transfer agent for the RAFT polymerization of the second monomer. TEM, TGA FTIR and XPS measurements indicated that MNPs were successfully modified. The diblock copolymer brushes decrease the nonspecific adsorption of proteins on MNPs. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：873 / 878

页数：6

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