vasculitis;
drugs;
musculoskeletal and joint diseases;
musculoskeletal syndromes;
D O I:
10.1136/bcr-2021-248477
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Polyarteritis nodosa (PAN) is a medium vessel vasculitis with necrotising vascular changes along with multisystemic involvement. Due to variable initial presentations, diagnosis of systemic PAN in children requires a comprehensive work up. In addition, systemic PAN needs an aggressive therapy. Mycophenolate mofetil is an emerging newer alternative for the treatment of PAN. We report a case of childhood systemic PAN who initially presented with subtle signs like reduced sensation over lateral foot, non-deforming arthritis and multiform rashes. After comprehensive aetiological work up, nerve biopsy and supporting evidence clinched the diagnosis. Vasculitis in children presenting with benign subtle signs is sometimes a diagnostic challenge to clinicians. Our case highlights the importance of lateral thinking while dealing with non-specific multisystemic signs. Evidence of successful treatment of PAN with mycophenolate mofetil is gradually being built up. It is also described to result lower relapse and increased treatment free survival rate.
机构:
UCL, Great Ormond St Inst Child Hlth, London, England
Great Ormond St Hosp Children NHS Fdn Trust, London, EnglandUCL, Great Ormond St Inst Child Hlth, London, England
Brogan, Paul A.
Arch, Barbara
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机构:
Univ Liverpool, Liverpool, Merseyside, EnglandUCL, Great Ormond St Inst Child Hlth, London, England
Arch, Barbara
Hickey, Helen
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机构:
Univ Liverpool, Liverpool, Merseyside, EnglandUCL, Great Ormond St Inst Child Hlth, London, England
Hickey, Helen
Anton, Jordi
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机构:
St Joan Deu Hosp, Barcelona, SpainUCL, Great Ormond St Inst Child Hlth, London, England
Anton, Jordi
Iglesias, Este
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机构:
St Joan Deu Hosp, Barcelona, SpainUCL, Great Ormond St Inst Child Hlth, London, England
Iglesias, Este
Baildam, Eileen
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机构:
Alder Hey Childrens NHS Fdn Trust, Liverpool, Merseyside, EnglandUCL, Great Ormond St Inst Child Hlth, London, England
Baildam, Eileen
Mahmood, Kamran
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h-index: 0
机构:
Alder Hey Childrens NHS Fdn Trust, Liverpool, Merseyside, EnglandUCL, Great Ormond St Inst Child Hlth, London, England
Mahmood, Kamran
Cleary, Gavin
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h-index: 0
机构:
Alder Hey Childrens NHS Fdn Trust, Liverpool, Merseyside, EnglandUCL, Great Ormond St Inst Child Hlth, London, England
Cleary, Gavin
Moraitis, Elena
论文数: 0引用数: 0
h-index: 0
机构:
Great Ormond St Hosp Children NHS Fdn Trust, London, EnglandUCL, Great Ormond St Inst Child Hlth, London, England
Moraitis, Elena
Papadopoulou, Charalampia
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机构:
Great Ormond St Hosp Children NHS Fdn Trust, London, EnglandUCL, Great Ormond St Inst Child Hlth, London, England
Papadopoulou, Charalampia
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Beresford, Michael W.
Riley, Phil
论文数: 0引用数: 0
h-index: 0
机构:
Royal Manchester Childrens Hosp, Manchester, Lancs, EnglandUCL, Great Ormond St Inst Child Hlth, London, England
Riley, Phil
Demir, Selcan
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机构:
Hacettepe Univ, Ankara, TurkeyUCL, Great Ormond St Inst Child Hlth, London, England
Demir, Selcan
Ozen, Seza
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h-index: 0
机构:
Hacettepe Univ, Ankara, TurkeyUCL, Great Ormond St Inst Child Hlth, London, England
Ozen, Seza
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Culeddu, Giovanna
Hughes, Dyfrig A.
论文数: 0引用数: 0
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机构:
Bangor Univ, Bangor, Gwynedd, WalesUCL, Great Ormond St Inst Child Hlth, London, England
Hughes, Dyfrig A.
Dolezalova, Pavla
论文数: 0引用数: 0
h-index: 0
机构:
Gen Univ Hosp Prague, Prague, Czech Republic
Charles Univ Prague, Prague, Czech RepublicUCL, Great Ormond St Inst Child Hlth, London, England
Dolezalova, Pavla
Hampson, Lisa, V
论文数: 0引用数: 0
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机构:
Univ Lancaster, Lancaster, EnglandUCL, Great Ormond St Inst Child Hlth, London, England
Hampson, Lisa, V
Whitehead, John
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机构:
Univ Lancaster, Lancaster, EnglandUCL, Great Ormond St Inst Child Hlth, London, England
Whitehead, John
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Jayne, David
Ruperto, Nicola
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机构:
IRCCS, Inst Giannina Gaslini, UOSID Ctr Trial, Genoa, ItalyUCL, Great Ormond St Inst Child Hlth, London, England
Ruperto, Nicola
Eleftheriou, Despina
论文数: 0引用数: 0
h-index: 0
机构:
UCL, Great Ormond St Inst Child Hlth, London, England
Great Ormond St Hosp Children NHS Fdn Trust, London, EnglandUCL, Great Ormond St Inst Child Hlth, London, England