Assessment of cancer cell migration using a viscosity-sensitive fluorescent probe

被引：34
作者：
Pan, Xiaohong [1 ,2 ]
Wang, Cheng [2 ]
Zhao, Congcong [1 ]
Cheng, Tingting [2 ]
Zheng, Aishan [1 ]
Cao, Yuru [3 ]
Xu, Kehua [1 ]
机构：
[1] Shandong Normal Univ, Collaborat Innovat Ctr Functionalized Probes Chem, Coll Chem Chem Engn & Mat Sci, Key Lab Mol & Nano Probes,Minist Educ, Jinan 250014, Peoples R China
[2] Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China
[3] Binzhou Med Univ, Med Coll 2, Yantai 264003, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2022年 / 58卷 / 29期
基金：
中国国家自然科学基金;
关键词：
BLOOD-VISCOSITY; LIVING CELLS; SENSOR;
D O I：
10.1039/d1cc07235h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel viscosity probe (NV1) was developed for assessing cancer cell migration. NV1 can respond to changes of viscosity rapidly and exhibits high sensitivity in HepG2 cells treated with starvation, rotenone and nystatin. Importantly, NV1 was used for the first time to evaluate the relationship between intracellular viscosity changes and cancer cell migration and proved that increased intracellular viscosity inhibits cell migration while decreased intracellular viscosity promotes cell migration.
引用
收藏
页码：4663 / 4666
页数：4
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