The immune system in aging: Roles of cytokines, T cells and NK cells

被引：71
|
作者：
Huang, H
Patel, DD
Manton, KG
机构：
[1] Duke Univ, Ctr Demog Studies, Durham, NC 27708 USA
[2] Univ N Carolina, Thurston Arthrit Res Ctr, Chapel Hill, NC 27599 USA
来源：
FRONTIERS IN BIOSCIENCE-LANDMARK | 2005年 / 10卷
关键词：
inflammatory Cytokines; interleukin-6; IL-6; tumor necrosis factor-alpha; TNF-a; aging; T cells; NK cells; review;
D O I：
10.2741/1521
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Aging is characterized by a proinflammatory state that contributes to the onset of disability and age-related diseases. Proinflammatory cytokines play a central role in mediating cellular and physiological responses. The levels of these cytokines may reflect immune system effectiveness. Studies of the effects of aging on inflammatory response show interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and interleukin - 1beta (IL-1beta) to be important. In this review, age-related changes in inflammatory cytokines, T and NK cells, and the biology of IL-6 and TNF-alpha and their relevance to senescence are considered.
引用
收藏
页码：192 / 215
页数：24
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