Functionalized cyclopentadienyl titanium organometallic compounds as new antitumor drugs

被引：127
|
作者：
Allen, OR
Croll, L
Gott, AL
Knox, RJ
McGowan, PC
机构：
[1] Univ Leeds, Dept Chem, Leeds LS2 9JT, W Yorkshire, England
[2] Enact Pharma PLC, Salisbury SP4 0JQ, Wilts, England
来源：
ORGANOMETALLICS | 2004年 / 23卷 / 02期
关键词：
D O I：
10.1021/om030403i
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A number of new ionic titanocene compounds have been isolated and characterized. These exhibit significant cytotoxicity against a number of different human tumor cell lines including a defined cisplatin-resistant cell line. One of the compounds is an order of magnitude more active than its nonfunctionalized equivalent.
引用
收藏
页码：288 / 292
页数：5
相关论文
共 50 条
  • [31] Antitumor titanium compounds and related metallocenes
    Caruso, F
    Rossi, M
    METAL IONS IN BIOLGICAL SYSTEMS, VOL 42: METAL COMPLEXES IN TUMOR DIAGNOSIS AND AS ANTICANCER AGENTS, 2004, 42 : 353 - 384
  • [32] STUDIES ON ORGANOMETALLIC COMPOUNDS OF TITANIUM, ZIRCONIUM AND HAFNIUM
    陈寿山
    刘以寅
    玄镇爱
    张正之
    Science Bulletin, 1980, (01) : 44 - 46
  • [33] Organometallic Antitumor Compounds: Ferrocifens as Precursors to Quinone Methides
    Wang, Yong
    Pigeon, Pascal
    Top, Siden
    McGlinchey, Michael J.
    Jaouen, Gerard
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2015, 54 (35) : 10230 - 10233
  • [34] STUDIES ON ORGANOMETALLIC COMPOUNDS OF TITANIUM,ZIRCONIUM AND HAFNIUM——THE SYNTHESES AND PROPERTIES OF BIS (CYCLOPENTADIENYL) AND BIS (METHYLCYCLOPENTADIENYL) DI(ARYL)-METAL DERIVATIVES
    陈寿山
    刘以寅
    王积涛
    Science in China,SerB., 1982, Ser.B.1982 (04) : 341 - 348
  • [35] The formation and polymerization behavior of (pentafluorophenyl)-cyclopentadienyl titanium compounds
    Maldanis, RJ
    Chien, JCW
    Rausch, MD
    JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2000, 599 (02) : 107 - 111
  • [36] STUDIES ON ORGANOMETALLIC COMPOUNDS OF TITANIUM, ZIRCONIUM AND HAFNIUM——SYNTHESIS AND ~1HNMR OF BIS(CYCLOPENTADIENYL)DI(ARYLOXY) METAL DERIVATIVES
    陈寿山
    刘以寅
    王积涛
    A Monthly Journal of Science, 1981, (10) : 893 - 896
  • [37] Review of Atypical Organometallic Compounds as Antimalarial Drugs
    Kwofie, Samuel K.
    Broni, Emmanuel
    Dankwa, Bismark
    Enninful, Kweku S.
    Teye, Joshua
    Davidson, Cedar R.
    Nimely, Josephine B.
    Chioma Orizu, J.
    Kempaiah, Prakasha
    Rathi, Brijesh
    Miller, Whelton A., III
    JOURNAL OF CHEMISTRY, 2020, 2020
  • [38] Functionalised cyclopentadienyl zirconium compounds as potential anticancer drugs
    Allen, Olivia R.
    Knox, Richard J.
    McGowan, Patrick C.
    DALTON TRANSACTIONS, 2008, (39) : 1293 - 1295
  • [39] Zirconium and titanium complexes with side-chain functionalized cyclopentadienyl ligands
    D. P. Krut’ko
    Russian Chemical Bulletin, 2009, 58 : 1745 - 1771
  • [40] Functionalized porous organometallic compounds as inhibitor of cell division
    Bashir, Sajid
    Martinez, Baldemar
    Liu, Jingbo
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 253
12345