Functionalized cyclopentadienyl titanium organometallic compounds as new antitumor drugs

被引：127

作者：

Allen, OR

Croll, L

Gott, AL

Knox, RJ

McGowan, PC

机构：

[1] Univ Leeds, Dept Chem, Leeds LS2 9JT, W Yorkshire, England

[2] Enact Pharma PLC, Salisbury SP4 0JQ, Wilts, England

来源：

ORGANOMETALLICS | 2004年 / 23卷 / 02期

关键词：

D O I：

10.1021/om030403i

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A number of new ionic titanocene compounds have been isolated and characterized. These exhibit significant cytotoxicity against a number of different human tumor cell lines including a defined cisplatin-resistant cell line. One of the compounds is an order of magnitude more active than its nonfunctionalized equivalent.

引用

页码：288 / 292

页数：5

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