Functionalized cyclopentadienyl titanium organometallic compounds as new antitumor drugs

被引：127
|
作者：
Allen, OR
Croll, L
Gott, AL
Knox, RJ
McGowan, PC
机构：
[1] Univ Leeds, Dept Chem, Leeds LS2 9JT, W Yorkshire, England
[2] Enact Pharma PLC, Salisbury SP4 0JQ, Wilts, England
来源：
ORGANOMETALLICS | 2004年 / 23卷 / 02期
关键词：
D O I：
10.1021/om030403i
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A number of new ionic titanocene compounds have been isolated and characterized. These exhibit significant cytotoxicity against a number of different human tumor cell lines including a defined cisplatin-resistant cell line. One of the compounds is an order of magnitude more active than its nonfunctionalized equivalent.
引用
收藏
页码：288 / 292
页数：5
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