New Carboxamides and a New Polyketide from the Sponge-Derived Fungus Arthrinium sp. SCSIO 41421

被引：8
|
作者：
She, Jianglian [1 ,2 ,3 ]
Chen, Yi [1 ,2 ,3 ]
Ye, Yuxiu [4 ]
Lin, Xiuping [1 ]
Yang, Bin [1 ]
Xiao, Jiao [5 ]
Liu, Yonghong [1 ,2 ,3 ]
Zhou, Xuefeng [1 ,2 ,3 ]
机构：
[1] Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, South China Sea Inst Oceanol, Guangzhou 510301, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[3] Southern Marine Sci & Engn Guangdong Lab Guangzho, Guangzhou 511458, Peoples R China
[4] Guangxi Univ Chinese Med, Inst Marine Drugs, Nanning 530200, Peoples R China
[5] Shenyang Pharmaceut Univ, Wuya Coll Innovat, Shenyang 110016, Peoples R China
来源：
MARINE DRUGS | 2022年 / 20卷 / 08期
基金：
中国国家自然科学基金;
关键词：
sponge-derived fungus; Arthrinium sp; carboxamides; acetylcholinesterase; DERIVATIVES; CONSTITUENTS;
D O I：
10.3390/md20080475
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
New carboxamides, (+/-)-vochysiamide C (1) and (+)-vochysiamide B (2), and a new polyketide, 4S,3aS,9aR-3a,9a-deoxy-3a hydroxy-1-dehydroxyarthrinone (3), were isolated and identified from the sponge-derived fungus Arthrinium sp. SCSIO 41421, together with other fifteen known natural products (4-18). Their structures including absolute configurations were determined by detailed NMR, MS spectroscopic analyses, calculated electronic circular dichroism (ECD), as well as quantum-chemical NMR calculations. Preliminary bioactivity screening and molecular docking analysis revealed that several natural products exhibited obvious enzyme inhibitory activities against acetylcholinesterase (AChE), such as 2,3,6,8-tetrahydroxy-1-methylxanthone (4) with an inhibitory rate 86% at 50 mu g/mL.
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页数：10
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