New Carboxamides and a New Polyketide from the Sponge-Derived Fungus Arthrinium sp. SCSIO 41421

被引：10

作者：

She, Jianglian ^{[1
,2
,3
]}

Chen, Yi ^{[1
,2
,3
]}

Ye, Yuxiu ^{[4
]}

Lin, Xiuping ^{[1
]}

Yang, Bin ^{[1
]}

Xiao, Jiao ^{[5
]}

Liu, Yonghong ^{[1
,2
,3
]}

Zhou, Xuefeng ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, South China Sea Inst Oceanol, Guangzhou 510301, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[3] Southern Marine Sci & Engn Guangdong Lab Guangzho, Guangzhou 511458, Peoples R China

[4] Guangxi Univ Chinese Med, Inst Marine Drugs, Nanning 530200, Peoples R China

[5] Shenyang Pharmaceut Univ, Wuya Coll Innovat, Shenyang 110016, Peoples R China

来源：

MARINE DRUGS | 2022年 / 20卷 / 08期

基金：

中国国家自然科学基金;

关键词：

sponge-derived fungus; Arthrinium sp; carboxamides; acetylcholinesterase; DERIVATIVES; CONSTITUENTS;

D O I：

10.3390/md20080475

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

New carboxamides, (+/-)-vochysiamide C (1) and (+)-vochysiamide B (2), and a new polyketide, 4S,3aS,9aR-3a,9a-deoxy-3a hydroxy-1-dehydroxyarthrinone (3), were isolated and identified from the sponge-derived fungus Arthrinium sp. SCSIO 41421, together with other fifteen known natural products (4-18). Their structures including absolute configurations were determined by detailed NMR, MS spectroscopic analyses, calculated electronic circular dichroism (ECD), as well as quantum-chemical NMR calculations. Preliminary bioactivity screening and molecular docking analysis revealed that several natural products exhibited obvious enzyme inhibitory activities against acetylcholinesterase (AChE), such as 2,3,6,8-tetrahydroxy-1-methylxanthone (4) with an inhibitory rate 86% at 50 mu g/mL.

引用

页数：10

共 34 条

[1]

[Anonymous], Molclus program, Version 1.10.

[2] Bioactive Polyketide and Diketopiperazine Derivatives from the Mangrove-Sediment-Derived Fungus Aspergillus sp. SCSIO41407 [J].