Nano Encapsulated Curcumin: And Its Potential for Biomedical Applications

被引：140

作者：

Chen, Yan ^{[1
]}

Lu, Yao ^{[1
]}

Lee, Robert J. ^{[2
]}

Xiang, Guangya ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Sch Pharm, Tongji Med Coll, Hangkong Rd 13, Wuhan 430030, Hubei, Peoples R China

[2] Ohio State Univ, Div Pharmaceut & Pharmacol, Columbus, OH 43210 USA

来源：

INTERNATIONAL JOURNAL OF NANOMEDICINE | 2020年 / 15卷

基金：

中国国家自然科学基金;

关键词：

curcumin; nanoformulations; bioavailability; nanoparticles; therapy; MESOPOROUS SILICA NANOPARTICLES; SOLID LIPID NANOPARTICLES; DRUG-DELIVERY SYSTEM; BOVINE SERUM-ALBUMIN; LOADED PLGA NANOPARTICLES; IN-VITRO; POLYMERIC NANOPARTICLES; CHITOSAN NANOPARTICLES; LIPOSOMAL CURCUMIN; CONTROLLED-RELEASE;

D O I：

10.2147/IJN.S210320

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Curcumin, a yellow-colored polyphenol extracted from the rhizome of turmeric root, is commonly used as a spice and nutritional supplement. It exhibits many pharmacological activities such as anti-inflammatory, anti-bacterial, anti-cancer, anti-Alzheimer, and anti-fungal. However, the therapeutic application of curcumin is limited by its extremely low solubility in aqueous buffer, instability in body fluids, and rapid metabolism. Nano delivery system has shown excellent potential to improve the solubility, biocompatibility and therapeutic effect of curcumin. In this review, we focus on the recent development of nano encapsulated curcumin and its potential for biomedical applications.

引用

页码：3099 / 3120

页数：22

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