Relationship between Nutrition, Lifestyle, and Neurodegenerative Disease: Lessons from ADH1B, CYP1A2 and MTHFR

被引:2
作者
Barati, Shila [1 ]
Fabrizio, Carlo [2 ]
Strafella, Claudia [1 ]
Cascella, Raffaella [3 ,4 ]
Caputo, Valerio [1 ]
Megalizzi, Domenica [1 ]
Peconi, Cristina [1 ]
Mela, Julia [1 ]
Colantoni, Luca [1 ]
Caltagirone, Carlo [5 ]
Termine, Andrea [2 ]
Giardina, Emiliano [1 ,3 ]
机构
[1] Santa Lucia Fdn IRCCS, Genom Med Lab UILDM, I-00179 Rome, Italy
[2] Santa Lucia Fdn IRCCS, Data Sci Unit, I-00143 Rome, Italy
[3] Tor Vergata Univ, Dept Biomed & Prevent, I-00133 Rome, Italy
[4] Catholic Univ Our Lady Good Counsel, Dept Biomed Sci, Tirana 1000, Albania
[5] Santa Lucia Fdn IRCCS, Dept Clin & Behav Neurol, I-00179 Rome, Italy
关键词
nutrition; neurodegeneration; epigenetics; nutrigenomics; SNPs; physical exercise; microbiota; metabolism; Alzheimer's disease; Parkinson's disease; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; PHYSICAL-ACTIVITY; APOLIPOPROTEIN-E; COGNITIVE IMPAIRMENT; CAFFEINE INTAKE; MOUSE MODEL; RISK; CONSUMPTION; EXERCISE;
D O I
10.3390/genes13081498
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
In the present review, the main features involved in the susceptibility and progression of neurodegenerative disorders (NDDs) have been discussed, with the purpose of highlighting their potential application for promoting the management and treatment of patients with NDDs. In particular, the impact of genetic and epigenetic factors, nutrients, and lifestyle will be presented, with particular emphasis on Alzheimer's disease (AD) and Parkinson's disease (PD). Metabolism, dietary habits, physical exercise and microbiota are part of a complex network that is crucial for brain function and preservation. This complex equilibrium can be disrupted by genetic, epigenetic, and environmental factors causing perturbations in central nervous system homeostasis, contributing thereby to neuroinflammation and neurodegeneration. Diet and physical activity can directly act on epigenetic modifications, which, in turn, alter the expression of specific genes involved in NDDs onset and progression. On this subject, the introduction of nutrigenomics shed light on the main molecular players involved in the modulation of health and disease status. In particular, the review presents data concerning the impact of ADH1B, CYP1A2, and MTHFR on the susceptibility and progression of NDDs (especially AD and PD) and how they may be exploited for developing precision medicine strategies for the disease treatment and management.
引用
收藏
页数:14
相关论文
共 50 条
  • [31] Caffeine Consumption and Interaction with ADORA2A, CYP1A2 and NOS1 Variants Do Not Influence Age at Onset of Machado-Joseph Disease
    Martins, Ana Carolina
    Pinheiro, Jordania dos Santos
    Szinwelski, Luciana
    Cidade, Eduardo Rockenbach
    Santin, Danilo Fernando
    Proenca, Laura Damke
    Araujo, Bruna Almeida
    Saraiva-Pereira, Maria Luiza
    Jardim, Laura Bannach
    CEREBELLUM, 2024, 23 (06) : 2217 - 2225
  • [32] Activation of aflatoxin B1 by expression of human CYP1A2 polymorphisms in Saccharomyces cerevisiae
    Fasullo, Michael
    Smith, Autumn
    Egner, Patricia
    Cera, Cinzia
    MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2014, 761 : 18 - 26
  • [33] Association between hypertension and coffee drinking based on CYP1A2 rs762551 single nucleotide polymorphism in Taiwanese
    Hou, Chien-Chou
    Tantoh, Disline Manli
    Lin, Chuan-Chao
    Chen, Pei-Hsin
    Yang, Hao-Jan
    Liaw, Yung-Po
    NUTRITION & METABOLISM, 2021, 18 (01)
  • [34] Induction of CYP1A1, CYP1A2, CYP1B1, increased oxidative stress and inflammation in the lung and liver tissues of rats exposed to incense smoke
    Hussain, Tajamul
    Al-Attas, Omar S.
    Al-Daghri, Nasser M.
    Mohammed, Arif A.
    De Rosas, Edgard
    Ibrahim, Shebl
    Vinodson, Benjamin
    Ansari, Mohammed G.
    El-Din, Khaled I. Alam
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 2014, 391 (1-2) : 127 - 136
  • [35] Design, synthesis and evaluation of the inhibitory selectivity of novel trans-resveratrol analogues on human recombinant CYP1A1, CYP1A2 and CYP1B1
    Mikstacka, Renata
    Rimando, Agnes M.
    Dutkiewicz, Zbigniew
    Stefanski, Tomasz
    Sobiak, Stanislaw
    BIOORGANIC & MEDICINAL CHEMISTRY, 2012, 20 (17) : 5117 - 5126
  • [36] Relationship between esophageal squamous cell carcinoma risk and alcohol-related ALDH2 and ADH1B polymorphisms: Evidence from a meta-analysis and Mendelian randomization analysis
    Zhang, Biao
    Peng, Yu-Hui
    Luo, Yun
    Hong, Chao-Qun
    Lin, Yi-Wei
    Zhang, Yu-Ling
    Xu, Yi-Wei
    Su, Xue-Fen
    Wu, Fang-Cai
    CANCER MEDICINE, 2023, 12 (20): : 20437 - 20449
  • [37] Response to Hill-Burns et al. letter: An attempt to replicate interaction between coffee and CYP1A2 gene in connection to Parkinson's disease
    Popat, R. A.
    Van Den Eeden, S. K.
    Tanner, M.
    Kamel, F.
    Umbach, D. M.
    Marder, K.
    Ritz, B.
    Ross, G. Webster
    Petrovitch, H.
    Topol, B.
    McGuire, V.
    Nelson, L. M.
    EUROPEAN JOURNAL OF NEUROLOGY, 2011, 18 (09) : E109 - E109
  • [38] CYP1A2, 2A13, and 3A4 network and interaction with aflatoxin B1
    Khan, M. Tahir
    Irfan, M.
    Ahsan, H.
    Ali, S.
    Malik, A.
    Pech-Cervantes, A. A.
    Cui, Z.
    Zhang, Y. J.
    Wei, D. Q.
    WORLD MYCOTOXIN JOURNAL, 2021, 14 (02) : 179 - 189
  • [39] CYP1A2 genotype modifies the association between coffee intake and the risk of hypertension
    Palatini, Paolo
    Ceolotto, Giulio
    Ragazzo, Fabio
    Dorigatti, Francesca
    Saladini, Francesca
    Papparella, Italia
    Mos, Lucio
    Zanata, Giuseppe
    Santonastaso, Massimo
    JOURNAL OF HYPERTENSION, 2009, 27 (08) : 1594 - 1601
  • [40] Characterization of differences in substrate specificity among CYP1A1, CYP1A2 and CYP1B1: an integrated approach employing molecular docking and molecular dynamics simulations
    Kesharwani, Siddharth S.
    Nandekar, Prajwal P.
    Pragyan, Preeti
    Rathod, Vijay
    Sangamwar, Abhay T.
    JOURNAL OF MOLECULAR RECOGNITION, 2016, 29 (08) : 370 - 390