End-wall effects for high aspect ratio (AR) turbulent duct flows under moderate spanwise rotation are investigated using Reynolds-Averaged Navier-Stokes (RANS) calculations with a Reynolds stress turbulence closure model. It is shown that despite an important uniformisation of the mean streamwise flow compared to the non-rotating case, the channel flow solution (AR=) is not recovered in practical high AR ducts used in experiments. The unavoidable end-wall generated secondary flow causes transverse advection which is capable of altering the mean velocity profile, even for AR as high as 22. In addition, for Re=40,000 and Ro=0.22, persistent longitudinal roll cells are found in the RANS solutions. The results suggest that their interaction with the secondary flow may challenge the prospect of formally reaching a steady, streamwise invariant regime in actual rotating duct experiments.