Role of Pseudomonas aeruginosa quorum-sensing systems in a mouse model of chronic respiratory infection

被引：20

作者：

Imamura, Y ^{[1
]}

Yanagihara, K ^{[1
]}

Tomono, K ^{[1
]}

Ohno, H ^{[1
]}

Higashiyama, Y ^{[1
]}

Miyazaki, Y ^{[1
]}

Hirakata, Y ^{[1
]}

Mizuta, Y ^{[1
]}

Kadota, J ^{[1
]}

Tsukamoto, K ^{[1
]}

Kohno, S ^{[1
]}

机构：

[1] Nagasaki Univ, Sch Med, Dept Internal Med 2, Nagasaki 8528501, Japan

来源：

JOURNAL OF MEDICAL MICROBIOLOGY | 2005年 / 54卷 / 06期

关键词：

D O I：

10.1099/jmm.0.46004-0

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The role of quorum-sensing systems in a mouse model of chronic Pseudomonas aeruginosa infection was studied. A chronic P. aeruginosa respiratory infection model was established by placement of a tube pre-coated with strain PAO1 (wild-type) or a quorum-sensing mutant, namely PAO-JP1 Delta lasl)), PDO100 (Delta rhl/) or PAO-JP2 (Delta lasll Delta rhl, in the bronchus. At day 14 after infection, the numbers of viable bacteria in the quorum-sensing-mutant groups were lower than in the wild-type group. Histopathological examination showed milder inflammatory changes in the lungs infected with the mutant groups compared with the wild-type group. In the bronchoalveolar lavage fluid from the quorum-sensing-system-mutant groups the proportion of neutrophils was lower than in wild-type group. These findings indicate that the quorum-sensing system plays an important role in chronic P. aeruginosa respiratory infection.

引用

页码：515 / 518

页数：4

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