Pulmonary manifestations of Sjogren's syndrome

被引:199
作者
Flament, Thomas [1 ]
Bigot, Adrien [2 ]
Chaigne, Benjamin [2 ]
Henique, Helene [1 ,2 ,3 ,4 ]
Diot, Elisabeth [2 ]
Marchand-Adam, Sylvain [1 ,3 ,4 ]
机构
[1] CHRU Tours, Serv Pneumol, Tours, France
[2] CHRU Tours, Serv Med Interne, Tours, France
[3] Univ Tours, UMR 1100, Tours, France
[4] INSERM, Ctr Etud Pathol Resp, UMR 1100, EA6305, Tours, France
关键词
LYMPHOCYTIC INTERSTITIAL PNEUMONIA; INCREASED BRONCHIAL RESPONSIVENESS; OBLITERANS ORGANIZING PNEUMONIA; HIGH-RESOLUTION CT; THIN-SECTION CT; QUALITY-OF-LIFE; LUNG-DISEASE; FOLLOW-UP; FOLLICULAR BRONCHIOLITIS; BRONCHOALVEOLAR LAVAGE;
D O I
10.1183/16000617.0011-2016
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
In 9-20% of cases, Sjogren's syndrome is associated with various respiratory symptoms. The most typical manifestations are chronic interstitial lung disease (ILD) and tracheobronchial disease. The most common manifestation of ILD is nonspecific interstitial pneumonia in its fibrosing variant. Other types of ILD, such as organising pneumonia, usual interstitial pneumonia and lymphocytic interstitial pneumonitis, are rare. Their radiological presentation is less distinctive, and definitive diagnosis may require the use of transbronchial or surgical lung biopsy. Corticosteroid therapy is the mainstay of ILD treatment in Sjogren's syndrome, but the use of other immunosuppressive drugs needs to be determined. ILD is a significant cause of death in Sjogren's syndrome. Tracheobronchial disease is common in Sjogren's syndrome, characterised by diffuse lymphocytic infiltration of the airway. It is sometimes responsible for a crippling chronic cough. It can also present in the form of bronchial hyperresponsiveness, bronchiectasis, bronchiolitis or recurrent respiratory infections. The management of these manifestations may require treatment for dryness and/or inflammation of the airways. Airway disease has little effect on respiratory function and is rarely the cause of death in Sjogren's syndrome patients. Rare respiratory complications such as amyloidosis, lymphoma or pulmonary hypertension should not be disregarded in Sjogren's syndrome patients.
引用
收藏
页码:110 / 123
页数:14
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