Evaluation of indices for predicting recovery of exercise tolerance in patients surviving allogenic hematopoietic stem cell transplantation

被引：3

作者：

Hamada, Ryota ^{[1
,2
]}

Kondo, Tadakazu ^{[3
]}

Harada, Kazuhiro ^{[2
]}

Murao, Masanobu ^{[1
,2
]}

Miyasaka, Junsuke ^{[1
]}

Yoshida, Michiko ^{[1
]}

Yonezawa, Honami ^{[1
]}

Nankaku, Manabu ^{[1
]}

Arai, Yasuyuki ^{[3
,4
]}

Kanda, Junya ^{[3
]}

Takaori-Kondo, Akifumi ^{[3
]}

Ikeguchi, Ryosuke ^{[1
]}

Matsuda, Shuichi ^{[1
]}

机构：

[1] Kyoto Univ Hosp, Rehabil Unit, Sakyo Ku, 54 Kawahara Cho, Kyoto 6068507, Japan

[2] Kibi Int Univ, Grad Sch Hlth Sci, Dept Phys Therapy, Okayama, Japan

[3] Kyoto Univ, Grad Sch Med, Dept Hematol & Oncol, Kyoto, Japan

[4] Kyoto Univ, Grad Sch Med, Dept Clin Lab Med, Kyoto, Japan

来源：

SUPPORTIVE CARE IN CANCER | 2022年 / 30卷 / 05期

基金：

日本学术振兴会;

关键词：

Hematopoietic stem cell transplantation; 6-min walk test; Knee extensor strength; Youden index; QUALITY-OF-LIFE; PHYSICAL-ACTIVITY; WALK TEST; CAPACITY; FITNESS; CANCER; THERAPY; TOOL;

D O I：

10.1007/s00520-022-06822-z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose Decline in physical function in the early stage after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a major challenge. Exercise tolerance tests, such as the 6-min walk test, are useful markers for predicting exercise tolerance and various other traits, including cardiometabolic risk and non-relapse mortality. This retrospective cohort study aimed to investigate and identify predictors of recovery of exercise tolerance in the early stage after allo-HSCT. Methods Ninety-eight patients were classified into recovery and non-recovery groups according to the median 6-min walk distance (6MWD) at discharge. Results Logistic regression analysis revealed that pre-post change in knee extensor strength (Delta KES) and hematopoietic cell transplantation comorbidity index were useful predictors of recovery of exercise tolerance at discharge and moderate predictors of 6MWD recovery in the early post-transplant period. Receiver operating characteristic analysis showed that pre-transplant Delta KES was an accurate predictor of 6MWD recovery in the early post-transplant period. The cutoff point for Delta KES calculated using the Youden index was - 1.17 Nm/kg. Conclusions The results of this study emphasize the importance of the need for programs designed to prevent muscle weakness in the early period after allo-HSCT. The results from markers of recovery of exercise tolerance are promising and can be used for patient education in rehabilitation programs after allo-HSCT.

引用

页码：4027 / 4034

页数：8

共 32 条

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