Self-Assembling Ligands for Multivalent Nanoscale Heparin Binding

被引：68

作者：

Rodrigo, Ana C. ^{[1
]}

Barnard, Anna ^{[1
]}

Cooper, James ^{[1
]}

Smith, David K. ^{[1
]}

机构：

[1] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 20期

基金：

英国生物技术与生命科学研究理事会;

关键词：

heparin; ligands; nanostructures; self-assembly; supramolecular chemistry; MOLECULAR-WEIGHT; DNA-BINDING; GENE DELIVERY; DENDRIMERS; DENDRONS; SULFATE; SURFACE; DESIGN; RECOGNITION; RECEPTORS;

D O I：

10.1002/anie.201100019

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Supramolecular string of pearls: Polycationic ligands are designed to self-assemble into spherical pseudo-dendrimers that are capable of binding polyanionic heparin with affinities and binding modes similar to covalent nanostructures such as dendrimers and proteins (see picture; purple: heparin, red/blue: self-assembling ligand). Binding of the ligands to heparin induces nanoscale organization of the formed nanostructures. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：4675 / 4679

页数：5

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