How does the promoter of an oocyte-specific gene function in male germ cells?

被引：1

作者：

Miki, Yuka ^{[1
]}

Tsukamoto, Satoshi ^{[2
]}

Minami, Naojiro ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Agr, Reprod Biol Lab, Kyoto 6068502, Japan

[2] Natl Inst Quantum & Radiol Sci & Technol, Lab Anim & Genome Sci Sect, Chiba 2638555, Japan

来源：

JOURNAL OF REPRODUCTION AND DEVELOPMENT | 2018年 / 64卷 / 06期

基金：

日本学术振兴会;

关键词：

DNA methylation; Epigenetics; Gene expression; Oocyte; Promoter; DNA METHYLATION; TRANSCRIPTIONAL REGULATION; EXPRESSION; GENOME; METHYLTRANSFERASES; DIFFERENTIATION; ENHANCER; PROTEIN; MEMORY; ALPHA;

D O I：

10.1262/jrd.2018-060

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

Studying gene expression in germ cells is useful for elucidating mechanisms of transcriptional regulation, because different genes are activated in male and female germ cells. The promoter regions of an oocyte-specific gene, Oog1, have been characterized. Driving the expression of green fluorescent protein with these different promoter regions provided us with critical information on the regulation of gene expression. The 3.9 kb long promoter functions in both male and female germ cells in transgenic mice. What is the cause of this sexually dimorphic expression? There may be important factors within and perhaps also outside this 3.9 kb promoter region that are required to maintain proper sex -specific gene expression.

引用

页码：463 / 468

页数：6

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