Mass spectrometric analysis of glucose-modified ribonuclease

被引：0

作者：

Cotham, WE

Hinton, DJS

Metz, TO

Brock, JWC

Thorpe, SR

Baynes, JW

Ames, JM ^{[1
]}

机构：

[1] Univ Reading, Sch Food Biosci, Hugh Sinclair Unit Human Nutr, Reading RG6 6AP, Berks, England

[2] Univ S Carolina, Dept Chem & Biochem, Columbia, SC 29208 USA

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2003年 / 31卷

关键词：

advanced glycatlon end product (AGE); NI-i(carboxymethyl)lysine; fructoselysine; glucose; LC-MS; RNase;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

RNase A (1 mM) was incubated with glucose (0.4 M) at 37degreesC for up to 14 days in phosphate buffer (0.2 M, pH 7.4), digested with trypsin and analysed by LC-MS. The major sites of fructoselysine formation were Lys(1), Lys(7), Lys(37) and Lys(41). Three of these sites (Lys(7), Lys(37) and Lys(41)) were also the major sites of N-epsilon-(carboxymethyl)lysine formation.

引用

页码：1426 / 1427

页数：2

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