Hydrogen Sulfide Prevents Sleep Deprivation-Induced Hippocampal Damage by Upregulation of Sirt1 in the Hippocampus

被引:21
|
作者
Zuo, Jin-Xi [1 ]
Li, Min [1 ]
Jiang, Li [1 ]
Lan, Fang [2 ,3 ]
Tang, Yi-Yun [4 ]
Kang, Xuan [4 ]
Zou, Wei [1 ]
Wang, Chun-Yan [4 ]
Zhang, Ping [1 ]
Tang, Xiao-Qing [3 ,4 ]
机构
[1] Univ South China, Affiliated Nanhua Hosp, Dept Neurol, Hengyang, Peoples R China
[2] Univ South China, Affiliated Hosp 1, Dept Neurol, Hengyang, Peoples R China
[3] Univ South China, Inst Neurol, Affiliated Hosp 1, Hengyang, Peoples R China
[4] Univ South China, Hengyang Med Coll, Dept Physiol, Hengyang, Peoples R China
基金
中国国家自然科学基金;
关键词
sleep deprivation; hydrogen sulfide; hippocampal damage; silence information regulating factor 1; oxidative stress; ENDOPLASMIC-RETICULUM STRESS; COGNITIVE DEFICITS; ALZHEIMERS-DISEASE; OXIDATIVE STRESS; MEMORY; APOPTOSIS; RATS; INVOLVEMENT; MECHANISMS; EXPRESSION;
D O I
10.3389/fnins.2020.00169
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Sleep deprivation (SD) induces hippocampal damage. Hydrogen sulfide (H2S) is a neuronal protective factor. Silence information regulating factor 1 (Sirt1) plays an important role in neuroprotection. Therefore, this study was aimed at exploring whether H2S meliorates SD-induced hippocampal damage and whether Sirt1 mediates this protective role of H2S. We found that sodium hydrosulfide (NaHS, a donor of H2S) alleviated SD-generated hippocampal oxidative stress, including increases in the activation of SOD and the level of GSH as well as a decrease in the level of MDA. Meanwhile, we found that NaHS reduced SD-exerted hippocampal endoplasmic reticulum (ER) Stress, including downregulations of GRP78, CHOP, and cleaved-caspase-12 expression. Moreover, NaHS reduced the apoptosis in the SD-exposed hippocampus, and this included decreases in the number of apoptotic cells and the activation of caspase-3, downregulation of Bax expression, and upregulation of Bcl-2 expression. NaHS upregulated the expression of Sirt1 in the hippocampus of SD-exposed rats. Furthermore, Sirtinol, the inhibitor of Sirt1, abrogated the protection of NaHS against SD-exerted hippocampal oxidative stress, ER stress, and apoptosis. These results suggested that H2S alleviates SD-induced hippocampal damage by upregulation of hippocampal Sirt1.
引用
收藏
页数:12
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