Characterisation of fluoroquinolone-resistant clinical isolates of Streptococcus pyogenes in Barcelona, Spain

被引：19
|
作者：
Rivera, A
Rebollo, M
Sánchez, F
Navarro, F
Miró, E
Mirelis, B
Coll, P
机构：
[1] Hosp Santa Creu & Sant Pau, Microbiol Serv, Barcelona 08025, Spain
[2] Univ Autonoma Barcelona, Dept Genet & Microbiol, Unitat Microbiol, E-08193 Barcelona, Spain
来源：
CLINICAL MICROBIOLOGY AND INFECTION | 2005年 / 11卷 / 09期
关键词：
epidemiology; gyrA; parC; quinolones; resistance; Streptococcus pyogenes;
D O I：
10.1111/j.1469-0691.2005.01216.x
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Resistance mechanisms and clonal relationships were determined for six Streptococcus pyogenes isolates with low- or high-level ciprofloxacin resistance. Four isolates displayed reduced susceptibility to ciprofloxacin and levofloxacin and had alterations in ParC: Ser80 -> Pro (isolate emm3.1); Ser79 -> Ala (two isolates emm6.0); and a double substitution Ser79 -> Phe and Ala121 -> Val (isolate emm12.27). Two isolates (emm12.26) displayed high-level resistance to ciprofloxacin and levofloxacin, as well as to other quinolones. These isolates had the same double substitution in ParC as isolate emm12.27, and an additional substitution (Ser81 -> Tyr) in GyrA. Resistance patterns, emm typing and sequencing of the quinolone resistance-determining regions defined two clusters containing three and two isolates, respectively.
引用
收藏
页码：759 / 761
页数：3
相关论文
共 50 条
  • [31] High Prevalence of Fluoroquinolone-Resistant Group B Streptococci among Clinical Isolates in China and Predominance of Sequence Type 19 with Serotype III
    Wang, Hui
    Zhao, Chunjiang
    He, Wenqiang
    Zhang, Feifei
    Zhang, Liyan
    Cao, Bin
    Sun, Ziyong
    Xu, Yingchun
    Yang, Qing
    Mei, Yaning
    Hu, Bijie
    Chu, Yunzhuo
    Liao, Kang
    Yu, Yunsong
    Hu, Zhidong
    Ni, Yuxing
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2013, 57 (03) : 1538 - 1541
  • [32] Detection of Mutation in 23S rRNA in Isolates of Streptococcus pyogenes Resistant to Erythromycin
    Sepehrizadeh, Z.
    Zarrini, G.
    Shapourabadi, M. Bahrololoumi
    Yazdi, M. Tabatabaei
    Shad, M. Hosseini
    IRANIAN JOURNAL OF PUBLIC HEALTH, 2008, 37 (04) : 114 - 118
  • [33] Susceptibility and bactericidal activity of 8 oral quinolones against conventional-fluoroquinolone-resistant Streptococcus pneumoniae clinical isolates
    Yokota, Shin-ichi
    Ohkoshi, Yasuo
    Fujii, Nobuhiro
    DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2009, 65 (01) : 76 - 80
  • [34] An extended PCR-RFLP assay for detection of parC, parE and gyrA mutations in fluoroquinolone-resistant Streptococcus pneumoniae
    Alonso, R
    Galimand, M
    Courvalin, P
    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2004, 53 (04) : 682 - 683
  • [35] Characterization of fluoroquinolone and carbapenem susceptibilities in clinical isolates of levofloxacin-resistant Pseudomonas aeruginosa
    Muramatsu, H
    Horii, T
    Takeshita, A
    Hashimoto, H
    Maekawa, M
    CHEMOTHERAPY, 2005, 51 (2-3) : 70 - 75
  • [36] Molecular epidemiology of fluoroquinolone resistance in invasive clinical isolates of Streptococcus pneumoniae in Seville
    Iraurgui, Patricia
    Jose Torres, Maria
    Aznar, Javier
    ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA, 2012, 30 (04): : 180 - 183
  • [37] Epidemiology and clinical features of Streptococcus pyogenes bloodstream infections in children in Madrid, Spain
    Cobo-Vazquez, Elvira
    Aguilera-Alonso, David
    Carbayo, Tania
    Figueroa-Ospina, Lucia M.
    Sanz-Santaeufemia, Francisco
    Baquero-Artigao, Fernando
    Vazquez-Ordonez, Carmen
    Carrasco-Colom, Jaime
    Blazquez-Gamero, Daniel
    Jimenez-Montero, Beatriz
    Grasa-Lozano, Carlos
    Cilleruelo, Maria Jose
    Alvarez, Ana
    Comin-Cabrera, Cristina
    Penin, Maria
    Cercenado, Emilia
    Del Valle, Rut
    Roa, Miguel Angel
    Garcia-De Diego, Irene
    Calvo, Cristina
    Saavedra-Lozano, Jesus
    EUROPEAN JOURNAL OF PEDIATRICS, 2023, 182 (07) : 3057 - 3062
  • [38] A mutation in QRDR in the ParC subunit of topoisomerase IV was responsible for fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae
    Choi, H
    Lee, HJ
    Lee, YH
    YONSEI MEDICAL JOURNAL, 1998, 39 (06) : 541 - 545
  • [39] In vitro activity of clinafloxacin against fluoroquinolone resistant Spanish clinical isolates
    López-Brea, M
    Prieto, N
    Domingo, D
    de las Cuevas, C
    Sánchez, I
    Alarcón, T
    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 1999, 12 (01) : 33 - 39
  • [40] Clinical, microbiological, and molecular characterization of pediatric invasive infections by Streptococcus pyogenes in Spain in a context of global outbreak
    de Arellano, Eva Ramirez
    Saavedra-Lozano, Jesus
    Villalon, Pilar
    Jove-Blanco, Ana
    Grandioso, David
    Sotelo, Jared
    Gamell, Anna
    Gonzalez-Lopez, Juan Jose
    Cervantes, Eloisa
    Gonzalez, Maria Jose
    Rello-Saltor, Victoria
    Esteva, Cristina
    Sanz-Santaeufemia, Francisco
    Yague, Genoveva
    Manzanares, Angela
    Branas, Patricia
    de Gopegui, Enrique Ruiz
    Carrasco-Colom, Jaime
    Garcia, Federico
    Cercenado, Emilia
    Mellado, Isabel
    del Castillo, Elena
    Perez-Vazquez, Maria
    Oteo-Iglesias, Jesus
    Calvo, Cristina
    MSPHERE, 2024, 9 (03)
12345