Characterisation of fluoroquinolone-resistant clinical isolates of Streptococcus pyogenes in Barcelona, Spain

被引：19
|
作者：
Rivera, A
Rebollo, M
Sánchez, F
Navarro, F
Miró, E
Mirelis, B
Coll, P
机构：
[1] Hosp Santa Creu & Sant Pau, Microbiol Serv, Barcelona 08025, Spain
[2] Univ Autonoma Barcelona, Dept Genet & Microbiol, Unitat Microbiol, E-08193 Barcelona, Spain
来源：
CLINICAL MICROBIOLOGY AND INFECTION | 2005年 / 11卷 / 09期
关键词：
epidemiology; gyrA; parC; quinolones; resistance; Streptococcus pyogenes;
D O I：
10.1111/j.1469-0691.2005.01216.x
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Resistance mechanisms and clonal relationships were determined for six Streptococcus pyogenes isolates with low- or high-level ciprofloxacin resistance. Four isolates displayed reduced susceptibility to ciprofloxacin and levofloxacin and had alterations in ParC: Ser80 -> Pro (isolate emm3.1); Ser79 -> Ala (two isolates emm6.0); and a double substitution Ser79 -> Phe and Ala121 -> Val (isolate emm12.27). Two isolates (emm12.26) displayed high-level resistance to ciprofloxacin and levofloxacin, as well as to other quinolones. These isolates had the same double substitution in ParC as isolate emm12.27, and an additional substitution (Ser81 -> Tyr) in GyrA. Resistance patterns, emm typing and sequencing of the quinolone resistance-determining regions defined two clusters containing three and two isolates, respectively.
引用
收藏
页码：759 / 761
页数：3
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