miR-193 expression differentiates telocytes from other stromal cells

被引：111
作者：
Cismasiu, V. B. [1 ,2 ]
Radu, E. [2 ]
Popescu, L. M. [1 ,2 ]
机构：
[1] Victor Babes Natl Inst Pathol, Dept Adv Studies & Pico & Nanotechnol, Bucharest 050096, Romania
[2] Carol Davila Univ Med & Pharm, Dept Cellular & Mol Med, Bucharest, Romania
来源：
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2011年 / 15卷 / 05期
关键词：
telocytes; telopodes; microRNA; laser capture microdissection; MICRORNAS; CARDIOMYOCYTE; EPICARDIUM; ICLC;
D O I：
10.1111/j.1582-4934.2011.01325.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Telocytes (TCs) are a particular type of interstitial (stromal) cells defined by very long, moniliform telopodes. Their tissue location, between blood vessels and other cells such as cardiomyocytes (CMC) and neurons, suggests a role in intercellular signalling. In order to define a microRNA (miR) signature in cardiac TCs, we have found that miR-193 is differentially expressed between TCs and other interstitial cells. Because miR-193 regulates c-kit, our data support the previous finding that TCs express c-kit in certain circumstances. In addition, the miRs which are specific to CMC and other muscle cells (e.g. miR-133a, miR-208a) are absent in TCs. Overall the data reinforce the view that TCs are a particular type of interstitial (mesenchymal) cells.
引用
收藏
页码：1071 / 1074
页数：4
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